Iopromide (6 brand names, 1 dosage form, 1 route)
Available dosage forms: INJECTABLE.
Routes of administration: INJECTION.
Brand Names
- ULTRAVIST (PHARMACY BULK)
- ULTRAVIST 150
- ULTRAVIST 240
- ULTRAVIST 300
- ULTRAVIST 300 IN PLASTIC CONTAINER
- ULTRAVIST 370
Indications and Usage
ULTRAVIST® Injection is an iodinated contrast agent indicated for:
Contraindications
None
Warnings and Precautions
Extravasation can occur with ULTRAVIST, particularly in patients with severe arterial or venous disease. Inflammation, blistering, skin necrosis, and compartment syndrome have been reported following extravasation. In addition, injection site reactions such as pain and swelling at the injection site can also occur [see Adverse Reactions ( 6.1)]. Ensure intravascular placement of catheters prior to injection. Monitor patients for extravasation and advise patients to seek medical care for progression of symptoms.
Adverse Reactions
The following adverse reactions are described elsewhere in the labeling: •Risks Associated with Intrathecal Use [see Warnings and Precautions (5.1)] •Hypersensitivity Reactions [see Warnings and Precautions (5.2)] •Acute Kidney Injury [see Warnings and Precautions (5.3)] •Cardiovascular Adverse Reactions [see Warnings and Precautions (5.4)] •Thromboembolic Events [see Warnings and Precautions (5.5)] •Extravasation and Injection Site Reactions [see Warnings and Precautions (5.6)] •Thyroid Dysfunction in Pediatric Patients 0 to 3 Years of Age [see Warnings and Precautions (5.8)] •Severe Cutaneous Adverse Reactions [see Warnings and Precautions (5.11)]
Mechanism of Action
Intravascular injection of iopromide opacifies those vessels where the contrast agent is present, permitting radiographic visualization of the internal structures through attenuation of photons. In imaging of the body, iodinated contrast agents diffuse from the vessels into the extravascular space. In normal brain with an intact blood-brain barrier, contrast does not diffuse into the extravascular space. In patients with a disrupted blood-brain barrier, contrast agent accumulates in the extravascular space in the region of disruption.
Overdosage
The manifestations of overdosage are life-threatening and affect mainly the pulmonary and cardiovascular systems. Treatment of an overdosage is directed toward the support of all vital functions, and prompt institution of symptomatic therapy. Iopromide can be removed by dialysis.