Hydrocortisone Butyrate (3 brand names, 4 dosage forms, 1 route)
Available dosage forms: CREAM, SOLUTION, LOTION, OINTMENT.
Routes of administration: TOPICAL.
Brand Names
- HYDROCORTISONE BUTYRATE
- LOCOID
- LOCOID LIPOCREAM
Indications and Usage
EVESSE™ (hydrocortisone butyrate) Lotion is indicated for the topical treatment of mild to moderate atopic dermatitis in patients 3 months of age and older.
Dosage and Administration
Apply EVESSE™ (hydrocortisone butyrate) Lotion for up to 2 weeks as a thin layer to the affected skin two times daily and rub in gently. Discontinue EVESSE™ (hydrocortisone butyrate) Lotion when control is achieved. If no improvement is seen within 2 weeks, consider reassessment of the diagnosis. Before prescribing for more than 2 weeks, the additional benefits of extending treatment up to 4 weeks should be weighed against the risk of endocrine system adverse reactions and local adverse reactions [see Warnings and Precautions (5.1), Adverse Reactions (6.1, 6.2)]. EVESSE™ (hydrocortisone butyrate) Lotion is not for oral, ophthalmic, or intravaginal use. Do not use EVESSE™ (hydrocortisone butyrate) Lotion [see Warnings and Precautions (5.1)]: With occlusive dressings unless directed by a healthcare provider. Avoid use in the diaper area, as diapers or plastic pants may constitute occlusive dressings. On the face, underarms, or groin areas unless directed by a healthcare provider.
Contraindications
None.
Adverse Reactions
The following adverse reactions are discussed in greater detail in other sections of the labeling: HPA axis suppression [see Warnings and Precautions (5.1), Use in Specific Populations (8.4)] Ophthalmic Adverse Reactions [see Warnings and Precautions (5.2)] Skin infections [see Warnings and Precautions (5.3)] Allergic contact dermatitis [see Warnings and Precautions (5.4)]
Mechanism of Action
Corticosteroids play a role in cellular signaling, immune function, inflammation, and protein regulation; however, the precise mechanism of action in atopic dermatitis is unknown.