Gonadorelin Hydrochloride (1 brand name, 1 dosage form, 1 route)
Available dosage forms: INJECTABLE.
Routes of administration: INJECTION.
Brand Names
- FACTREL
Dosage and Administration
For the treatment of ovarian follicular cysts in lactating dairy cows, beef cows, and replacement dairy and beef heifers: Administer 2 mL of FACTREL Injection as a single intramuscular injection. For use with LUTALYSE (dinoprost tromethamine injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows: Administer 2 to 4 mL FACTREL Injection (100-200 mcg gonadorelin) per cow as an intramuscular injection in a treatment regimen with the following framework:• Administer the first dose of FACTREL Injection (2-4 mL) at Day 0• Administer LUTALYSE (25 mg dinoprost, as dinoprost tromethamine injection) Injection by intramuscular injection 6-8 days after the first dose of FACTREL Injection.• Administer a second dose of FACTREL Injection (2-4 mL) 30 to 72 hours after the LUTALYSE injection.• Perform FTAI 0 to 24 hours after the second dose of FACTREL Injection, or inseminate cows on detected estrus using standard herd practices. Below are three examples of treatment regimens for FTAI that fit within the dosage regimen framework described immediately above: Example 1 Example 2 Example 3 Day 0 (Monday) 1st FACTREL 1st FACTREL 1st FACTREL Day 7 (the following Monday) LUTALYSE LUTALYSE LUTALYSE Day 9 (Wednesday) 2nd FACTREL + FTAI at 48 hours after LUTALYSE 2nd FACTREL 48 hours after LUTALYSE 2nd FACTREL 56 hours after LUTALYSE Day 10 (Thursday) FTAI 24 hours after 2nd FACTREL FTAI 18 hours after 2nd FACTREL
Mechanism of Action
Follicular cysts are enlarged non-ovulatory follicles resulting from a malfunction of the neuroendocrine mechanism controlling follicular maturation and ovulation. Exogenous administration of agents possessing luteinizing hormone (LH) activity, such as pituitary extracts or human chorionic gonadotropin, often causes ovulation or regression of follicular cysts. FACTREL Injection induces release of endogenous luteinizing hormone (LH) to produce this same effect. Gonadorelin, through release of LH has been demonstrated to induce ovulation of dominant ovarian follicles present on the bovine ovary during the estrous cycle. Administration of FACTREL Injection has the same effect.