Ganciclovir (5 brand names, 4 dosage forms, 4 routes)
Available dosage forms: IMPLANT, SOLUTION, CAPSULE, GEL.
Routes of administration: IMPLANTATION, INTRAVENOUS, ORAL, OPHTHALMIC.
Brand Names
- CYTOVENE
- GANCICLOVIR
- GANZYK-RTU
- VITRASERT
- ZIRGAN
Indications and Usage
ZIRGAN is indicated for the treatment of acute herpetic keratitis (dendritic ulcers) in adults and pediatric patients aged 2 years and older.
Dosage and Administration
The recommended dosage is 1 drop in the affected eye 5 times per day (approximately every 3 hours while awake) until the corneal ulcer heals, and then 1 drop 3 times per day for 7 days.
Contraindications
None.
Adverse Reactions
Most common adverse reactions reported in patients were blurred vision (60%), eye irritation (20%), punctate keratitis (5%), and conjunctival hyperemia (5%).
Mechanism of Action
ZIRGAN is an antiviral drug [ see Microbiology (12.4)] .