Gallium Ga-68 Gozetotide (4 brand names, 2 dosage forms, 1 route)
Available dosage forms: SOLUTION, POWDER.
Routes of administration: INTRAVENOUS.
Brand Names
- GALLIUM GA 68 GOZETOTIDE
- GOZELLIX
- ILLUCCIX
- LOCAMETZ
Indications and Usage
Gallium Ga 68 gozeotide injection is indicated for positron emission tomography (PET) of prostate-specific membrane antigen (PSMA) positive lesions in men with prostate cancer: with suspected metastasis who are candidates for initial definitive therapy. with suspected recurrence based on elevated serum prostate-specific antigen (PSA) level.
Contraindications
None
Mechanism of Action
Gallium Ga 68 gozetotode binds to prostate-specific membrane antigen (PSMA). It binds to cells that express PSMA, including malignant prostate cancer cells, which usually overexpress PSMA. Gallium-68 (Ga 68) is a β+ emitting radionuclide that allows positron emission tomography (PET).
Overdosage
In the event of an overdose of gallium Ga 68 gozetotide injection, reduce the radiation absorbed dose to the patient where possible by increasing the elimination of the drug from the body using hydration and frequent bladder voiding. A diuretic might also be considered. If possible, an estimate of the radiation effective dose given to the patient should be made.