Fosfomycin Disodium (1 brand name, 1 dosage form, 1 route)
Available dosage forms: POWDER.
Routes of administration: INTRAVENOUS.
Brand Names
- CONTEPO
Contraindications
CONTEPO is contraindicated in patients with known serious hypersensitivity to fosfomycin, or any of the excipients [ see Warnings and Precautions (5.2) ].
Adverse Reactions
The following adverse reactions are discussed in greater detail in the Warnings and Precautions section: Serum Electrolyte Abnormalities [see Warnings and Precautions (5.1)] QT Prolongation [see Warnings and Precautions (5.2)] Increased Transaminase Levels [see Warnings and Precautions (5.3)] Hypersensitivity Reactions [see Warnings and Precautions (5.4)] Neutropenia Including Agranulocytosis [see Warnings and Precautions (5.5)] Clostridioides difficile-Associated Diarrhea [see Warnings and Precautions (5.6)] Development of Drug-Resistant Bacteria [see Warnings and Precautions (5.7)]
Mechanism of Action
CONTEPO is an antibacterial drug [ see Microbiology (12.4) ].
Overdosage
To date, no cases of accidental overdose with clinically relevant intolerances have been reported. In the event of an overdose, the patient must be monitored and treated symptomatically. Fosfomycin is cleared from the body by hemodialysis, during which patients with end stage renal disease have an increased mean fosfomycin elimination half-life to approximately 4 hours.