Desloratadine (5 brand names, 5 dosage forms, 1 route)
Available dosage forms: TABLET, EXTENDED RELEASE, TABLET, SOLUTION, TABLET, ORALLY DISINTEGRATING, SYRUP.
Routes of administration: ORAL.
Brand Names
- CLARINEX
- CLARINEX D 24 HOUR
- CLARINEX-D 12 HOUR
- DESLORATADINE
- DESLORATADINE AND PSEUDOEPHEDRINE SULFATE 24 HOUR
Mechanism of Action
Desloratadine is a long-acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity. Receptor binding data indicates that at a concentration of 2 to 3 ng/mL (7 nanomolar), desloratadine shows significant interaction with the human histamine H1-receptor. Desloratadine inhibited histamine release from human mast cells in vitro. Results of a radiolabeled tissue distribution study in rats and a radioligand H1-receptor binding study in guinea pigs showed that desloratadine did not readily cross the blood brain barrier. The clinical significance of this finding is unknown.