Dehydrated Alcohol (2 brand names, 1 dosage form, 2 routes)
Available dosage forms: SOLUTION.
Routes of administration: INTRAVENOUS, INTRA-ARTERIAL.
Brand Names
- ABLYSINOL
- DEHYDRATED ALCOHOL
Related Health Topics
- Alcohol
- Alcohol Use Disorder (AUD)
- Fetal Alcohol Spectrum Disorders
- Alcohol Use Disorder (AUD) Treatment
Related Conditions
Indications and Usage
Dehydrated alcohol injection is indicated to induce controlled cardiac septal infarction to improve exercise capacity in adults with symptomatic hypertrophic obstructive cardiomyopathy who are not candidates for surgical myectomy.
Contraindications
None.
Adverse Reactions
Heart block [see Warnings and Precautions (5.1)]. The following other adverse reactions associated with percutaneous transluminal septal myocardial ablation with the use of dehydrated alcohol, such as dehydrated alcohol injection, were identified in the literature: Ventricular tachycardia and ventricular fibrillation.
Mechanism of Action
Dehydrated alcohol is a tissue toxin that produces a myocardial infarction when injected through an intra-arterial catheter into a target septal vessel, which causes the hypertrophied septum to thin.
Overdosage
There is a direct correlation between the volume of alcohol and size of iatrogenic myocardial infarction. Stop the procedure if there is failure to reduce the left ventricular outflow tract pressure gradient to less than 10 mmHg when reaching a total dose of 5 mL.