Cyclosporine (9 brand names, 4 dosage forms, 3 routes)
Available dosage forms: SOLUTION, CAPSULE, EMULSION, INJECTABLE.
Routes of administration: ORAL, OPHTHALMIC, INJECTION.
Brand Names
- CEQUA
- CYCLOSPORINE
- GENGRAF
- NEORAL
- RESTASIS
- RESTASIS MULTIDOSE
- SANDIMMUNE
- VERKAZIA
- VEVYE
Indications and Usage
CEQUA ophthalmic solution is a calcineurin inhibitor immunosuppressant indicated to increase tear production in patients with keratoconjunctivitis sicca (dry eye). (1)
Dosage and Administration
Instill one drop of CEQUA twice daily (approximately 12 hours apart) into each eye. CEQUA can be used concomitantly with artificial tears, allowing a 15 minute interval between products. Discard the vial immediately after using in both eyes. ( 2 )
Contraindications
None. (4)
Mechanism of Action
Cyclosporine is a calcineurin inhibitor immunosuppressant agent when administered systemically. In patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca, topical administration of cyclosporine is thought to act as a partial immunomodulator. The exact mechanism of action is not known.