Cosyntropin (2 brand names, 2 dosage forms, 2 routes)
Available dosage forms: INJECTABLE, SOLUTION.
Routes of administration: INJECTION, INTRAVENOUS.
Brand Names
- CORTROSYN
- COSYNTROPIN
Dosage and Administration
The dose is 0.25 mg (1 mL) per dog weighing 10–110 lbs (4.5–50 kg), administered by intravenous or intramuscular injection, with the purpose of performing the adrenocorticotropic hormone (ACTH) stimulation test. Discard unused portion. Cosacthen is provided in a single use vial and does not contain a preservative. Collect the first blood sample to measure the baseline cortisol concentration immediately prior to administering Cosacthen. Collect the second blood sample 1 hour after administration of Cosacthen to measure the dog’s cortisol concentration in response to Cosacthen.
Contraindications
Do not use Cosacthen in dogs that have previously had a hypersensitivity reaction to cosyntropin.
Adverse Reactions
In the field study using a non-final formulation cosyntropin injection, which included 119 dogs with suspected hypoadrenocorticism or hyperadrenocorticism, two dogs vomited within 8 hours after cosyntropin injection administration, and one dog developed a hematoma at the injection site after IV administration. Clinical pathology abnormalities were consistent with pre-existing hypoadrenocorticism and hyperadrenocorticism. Foreign Market Experience: The following adverse events were reported voluntarily during post-approval use of Cosacthen in dogs in foreign markets: lethargy, anxiety, muscle tremor/weakness, abdominal pain, anorexia, diarrhea, injection site pain/bruising, lameness, and hypersensitivity reactions. CONTACT INFORMATION To report suspected adverse drug experiences, or for technical assistance, contact Dechra Veterinary Products at (866) 933-2472. For additional information about reporting adverse drug experiences for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/reportanimalae