Cilastatin Sodium — Active Pharmaceutical Ingredient

Cilastatin Sodium is an active pharmaceutical ingredient found in 3 FDA-approved drug products. Forms: POWDER, INJECTABLE. Routes: INTRAVENOUS, INJECTION, INTRAMUSCULAR.

Drug Ingredients A–Z 1 min read
This content is for informational purposes only. Always consult a healthcare professional.

Cilastatin Sodium (3 brand names, 2 dosage forms, 3 routes)

Available dosage forms: POWDER, INJECTABLE.

Routes of administration: INTRAVENOUS, INJECTION, INTRAMUSCULAR.

Brand Names

  • IMIPENEM AND CILASTATIN
  • PRIMAXIN
  • RECARBRIO

Contraindications

PRIMAXIN is contraindicated in patients who have shown hypersensitivity to any component of this product.

Adverse Reactions

The following serious adverse reactions are described in greater detail in the Warnings and Precautions section. Hypersensitivity Reactions [see Warnings and Precautions (5.1)] Seizure Potential [see Warnings and Precautions (5.2)] Increased Seizure Potential Due to Interaction with Valproic Acid [see Warnings and Precautions (5.3)] Clostridioides difficile-Associated Diarrhea (CDAD) [see Warnings and Precautions (5.4)] Development of Drug-Resistant Bacteria [see Warnings and Precautions (5.5)]

Mechanism of Action

PRIMAXIN is a combination of imipenem and cilastatin. Imipenem is a penem antibacterial drug [see Microbiology (12.4)]. Cilastatin is a renal dehydropeptidase inhibitor that limits the renal metabolism of imipenem.

Overdosage

In the case of overdosage, discontinue PRIMAXIN, treat symptomatically, and institute supportive measures as required. PRIMAXIN is hemodialyzable.

⚠ Caution
Medical Disclaimer: This information is for educational purposes only. Always consult a healthcare professional before taking any medication.