Caspofungin Acetate (2 brand names, 1 dosage form, 1 route)
Available dosage forms: POWDER.
Routes of administration: INTRAVENOUS.
Brand Names
- CANCIDAS
- CASPOFUNGIN ACETATE
Contraindications
Caspofungin acetate for Injection is contraindicated in patients with known hypersensitivity (e.g., anaphylaxis) to any component of this product [see Adverse Reactions (6)].
Adverse Reactions
The following serious adverse reactions are discussed in detail in another section of the labeling: •Hypersensitivity [see Warnings and Precautions (5.1)] •Hepatic Effects [see Warnings and Precautions (5.2)] •Elevated Liver Enzymes During Concomitant Use with Cyclosporine [see Warnings and Precautions (5.3)]
Mechanism of Action
Caspofungin is an echinocandin antifungal drug [see Microbiology (12.4)].
Overdosage
In 6 healthy subjects who received a single 210 mg dose, no significant adverse reactions were reported Multiple doses above 150 mg daily have not been studied. Caspofungin is not dialyzable. In clinical trials, one pediatric patient (16 years of age) unintentionally received a single dose of caspofungin of 113 mg (on Day 1), followed by 80 mg daily for an additional 7 days. No clinically significant adverse reactions were reported.