Calcium Acetate — Active Pharmaceutical Ingredient

Calcium Acetate is an active pharmaceutical ingredient found in 6 FDA-approved drug products. Forms: TABLET, CAPSULE, INJECTABLE, SOLUTION. Routes: ORAL, INJECTION.

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Calcium Acetate (6 brand names, 4 dosage forms, 2 routes)

Available dosage forms: TABLET, CAPSULE, INJECTABLE, SOLUTION.

Routes of administration: ORAL, INJECTION.

Brand Names

  • CALCIUM ACETATE
  • ELIPHOS
  • PHOSLO
  • PHOSLO GELCAPS
  • PHOSLYRA
  • PROCALAMINE

Indications and Usage

Calcium acetate is a phosphate binder indicated to reduce serum phosphorus in patients with end stage renal disease (ESRD).

Dosage and Administration

The recommended initial dose of calcium acetate for the adult dialysis patient is 2 capsules with each meal. Increase the dose gradually to lower serum phosphorus levels to the target range, as long as hypercalcemia does not develop. Most patients require 3-4 capsules with each meal.

Contraindications

Patients with hypercalcemia.

Adverse Reactions

Hypercalcemia is discussed elsewhere [see Warnings and Precautions (5.1)]

Drug Interactions

The drug interaction of calcium acetate is characterized by the potential of calcium to bind to drugs with anionic functions (e.g., carboxyl, and hydroxyl groups). Calcium acetate may decrease the bioavailability of tetracyclines or fluoroquinolones via this mechanism. There are no empirical data on avoiding drug interactions between calcium acetate and most concomitant drugs. When administering an oral medication with calcium acetate where a reduction in the bioavailability of that medication would have a clinically significant effect on its safety or efficacy, administer the drug one hour before or three hours after calcium acetate. Monitor blood levels of the concomitant drugs that have a narrow therapeutic range. Patients taking anti-arrhythmic medications for the control of arrhythmias and anti-seizure medications for the control of seizure disorders were excluded from the clinical trials with all forms of calcium acetate.

Mechanism of Action

Calcium acetate, when taken with meals, combines with dietary phosphate to form an insoluble calcium phosphate complex, which is excreted in the feces, resulting in decreased serum phosphorus concentration.

Overdosage

Administration of calcium acetate in excess of the appropriate daily dosage may result in hypercalcemia [see Warnings and Precautions (5.1) ].

⚠ Caution
Medical Disclaimer: This information is for educational purposes only. Always consult a healthcare professional before taking any medication.