Atovaquone (5 brand names, 2 dosage forms, 1 route)
Available dosage forms: TABLET, SUSPENSION.
Routes of administration: ORAL.
Brand Names
- ATOVAQUONE
- ATOVAQUONE AND PROGUANIL HYDROCHLORIDE
- MALARONE
- MALARONE PEDIATRIC
- MEPRON
Contraindications
MEPRON oral suspension is contraindicated in patients who develop or have a history of hypersensitivity reactions to atovaquone or any of the components of MEPRON [see Warnings and Precautions (5.3), Adverse Reactions (6.2)].
Adverse Reactions
The following adverse reactions are discussed in another section of the labeling: •Hepatotoxicity [see Warnings and Precautions (5.2)]. •Severe Cutaneous Adverse Reactions [see Warnings and Precautions (5.3)].
Mechanism of Action
Atovaquone is a quinone antimicrobial drug [see Microbiology (12.4)].
Overdosage
Overdoses up to 31,500 mg of atovaquone have been reported. In one such patient who also took an unspecified dose of dapsone, methemoglobinemia occurred. Rash has also been reported after overdose. There is no known antidote for atovaquone, and it is currently unknown if atovaquone is dialyzable.