Articaine Hydrochloride (6 brand names, 2 dosage forms, 2 routes)
Available dosage forms: INJECTABLE, SOLUTION/DROPS.
Routes of administration: INJECTION, OPHTHALMIC.
Brand Names
- ARTICAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATE
- CYKLX
- ORABLOC
- SEPTOCAINE
- ULTACAN
- ULTACAN FORTE
Indications and Usage
CYKLX is indicated for ocular surface anesthesia prior to ocular procedures and/or intraocular injections in adults and pediatric patients.
Dosage and Administration
The recommended dose of CYKLX is 2 drops applied 30 seconds apart to the ocular surface.
Contraindications
CYKLX is contraindicated in patients with known hypersensitivity to any component of this preparation.
Mechanism of Action
Articaine hydrochloride is an amide local anesthetic. Local anesthetics block the generation and conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction velocity of the affected nerve fibers.
Overdosage
Acute emergencies from local anesthetics are generally related to high plasma levels encountered during therapeutic use of local anesthetics or to unintended subarachnoid injection of local anesthetic solution.