Albumin Human (1 brand name, 1 dosage form, 1 route)
Available dosage forms: INJECTABLE.
Routes of administration: INJECTION.
Brand Names
- OPTISON
Related Conditions
Dosage and Administration
ALBURX® 5, Albumin (Human) 5% solution must be administered intravenously. The venipuncture site should not be infected or traumatized, and should be prepared with standard aseptic technique. The solution is compatible with whole blood or packed red cells as well as the usual electrolyte and carbohydrate solutions intended for intravenous use. By contrast, it should not be mixed with protein hydrolysates, amino acid mixtures, or solutions containing alcohol. It is ready for use as contained in the bottle and may be given without regard to the blood group of the recipient. Upon administration of ALBURX® 5, Albumin (Human) 5% solution, there is a rapid increase of the plasma volume about equal to the volume infused. The initial dose for adults is 250 or 500 mL. The rate of infusion and the total volume administered are determined by the condition and response of the patient. A rate of 1–2 mL per minute is usually suitable in the absence of overt shock, whereas the capacity of the administration set is the only limit in the exsanguinated patient. During resuscitation, constant monitoring of the patient provides the guidelines for treatment. For children, a dose of 22 to 33 mL per kilogram body weight is usually adequate and close surveillance of the young patient is essential. Since patients – notably those with sepsis or severe multiple injuries – often need a circulating blood volume exceeding the prediction derived from their body weight, treatment should always be guided by the hemodynamic response and not by blood volume calculations or measurements.5 ALBURX® 5, Albumin (Human) 5% is clear and slightly viscous; it is almost colorless, or yellow, amber, or green. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use solution that is turbid or contains particulate matter. Partially used bottles must be discarded.
Contraindications
The use of ALBURX® 5, Albumin (Human) 5% solution is contraindicated in patients with a history of an incompatibility reaction to such preparations (see ADVERSE REACTIONS ). In addition, ALBURX® 5 may be contraindicated in patients with cardiac failure or severe anemia because of the risk of acute circulatory overload.
Adverse Reactions
Since ALBURX® 5, Albumin (Human) 5% solution is sterile when coming from the manufacturer, bacterial contamination with the risk of post-infusion septicemia can only occur if the container has been damaged or following puncture of the rubber cap (see WARNINGS ). Though very rare, non-septic incompatibility reactions including nausea, chills, fever, urticaria, headache and hypotension following the administration of albumin-containing preparations have occasionally been observed.6,8,9,16 A favorable response to the intravenous administration of 50 to 100 mg of prednisolone was recorded.9 Severe allergic reactions such as anaphylactic shock have been reported.