Acoramidis Hydrochloride — Active Pharmaceutical Ingredient

Acoramidis Hydrochloride (1 brand name, 1 dosage form, 1 route)

Available dosage forms: TABLET.

Routes of administration: ORAL.

Brand Names

• ATTRUBY

Indications and Usage

ATTRUBY is indicated for the treatment of the cardiomyopathy of wild-type or variant transthyretin-mediated amyloidosis (ATTR-CM) in adults to reduce cardiovascular death and cardiovascular-related hospitalization.

Contraindications

None.

Mechanism of Action

Acoramidis is a selective stabilizer of transthyretin (TTR). Acoramidis binds TTR at thyroxine binding sites and slows dissociation of the TTR tetramer into its constituent monomers, the rate-limiting step in amyloidogenesis.

Overdosage

There is no clinical experience with overdose. In case of suspected overdose, treatment should be symptomatic and supportive.