Clinical Trials for Voice Disorders

Source: ClinicalTrials.gov — U.S. National Library of Medicine — A database of privately and publicly funded clinical studies conducted around the world (U.S. National Library of Medicine, public domain).

This page lists clinical trials related to Voice Disorders from the ClinicalTrials.gov database.

Trial Summary

• Total studies: 50
• Recruiting: 15
• Active, not recruiting: 3
• Completed: 17
• Other: 15

Results are refreshed periodically and may not reflect the most current information available from ClinicalTrials.gov.

Recruiting Trials

NCT06416293 — Widening Aims and Giving Patients a Voice for Expanded Structures in Breast Cancer Care Jointly Developed by Patients and Physicians

The aim of this BZKF project is to record the current care structure for breast cancer patients in order to use this as a basis for developing possible future models for improvement. The active involvement of representatives of regional and national patient organizations in the creation of a patient-based and patient-oriented survey ensures that the needs of patients are the focus. In addition …

NCT05670496 — Collection of Clinical Data and Specimens for Research in Hearing, Balance, Taste, Smell, Voice, Speech, and Language Disorders.

Background:

People with hearing, balance, and taste, smell, voice, speech, language, and other Ear, Nose, and Throat (ENT) disorders may seek treatment at the National Institute on Deafness and Other Communication Disorders (NIDCD). Some of these people may benefit from enrolling in the NIDCD intramural research program to receive their care. Enrolling will also allow investigators to collect …

NCT05489965 — Gender Disparities in Voice Outcomes After Tracheoesophageal Puncture in Total Laryngectomy Patients (UC Davis)

To perform a multi-site prospective study assessing, both subjectively and objectively, the gender disparities in speech outcomes of patients using TEP after total laryngectomy.

The investigators hypothesize that speech outcomes, both subjective and objective measures, will be significantly poorer for female patients compared to male patients. The outcome of the study is to prospectively asses…

NCT07599696 — Speech Amplification Devices for Parkinson Disease: Talker- and Technology-Driven Enhancements

The proposed research aims to investigate the use of speech amplification devices as a potential treatment option for people with Parkinson’s disease and related disorders who exhibit hypophonia, a voice disorder that affects over half of those with Parkinson’s disease. By characterizing the acoustic and perceptual effects of speech amplification and identifying ways to optimize outcomes throug…

NCT06743490 — Capturing Key MG-symptoms Using Smartphone Recordings.

This study will make use of a cross-sectional design of MG patients and non-MG participants to quantitatively assess key MG symptoms, and to explore the applicability of machine learning algorithms to their measurement.

NCT06875843 — Project VOICES: Vocal Optimization in Children Elevating the Spectrum

Thirty percent of children with autism barely talk or do not talk at all despite years of intervention. This study aims to address this important and long-standing challenge by developing a novel intervention to increase the quantity and quality of vocalizations (i.e., sounds children make before words) and expressive language in young children with autism (aged 2 to 5 years) with minimal verba…

NCT07216326 — Our Voices Matter: Intervention for Depression in Youth

Over 15 million people participated in racial justice protests nationwide during 2020-2021 spotlighting activism as a collective tool against structural racism and discrimination (SRD). SRD manifests as policies and practices (e.g., redlining, voter suppression, mass incarceration) that produce hostile environments that contribute to psychological distress, elevated allostatic load, and an elev…

NCT06874322 — Voiceitt for People With Impairments in Speech

The primary objective of this pilot study is to evaluate the feasibility and preliminary effectiveness of the Voiceitt app in improving communication for individuals with speech impairments due to conditions such as cerebral palsy (CP), stroke, Amyotrophic Lateral Sclerosis (ALS), or Parkinson’s disease.

NCT06982261 — Voice Technology-Based Self-Management Intervention

This study aims to test a new technology-based program designed to help improve the ability to manage chronic conditions.

This program includes daily smart speaker use for managing different tasks and technology learning.

Proper self-management of chronic conditions is critical to the maintenance of health. Digital technologies offer substantial potential to enhance self-management behaviors….

NCT07165834 — Voices of Transformation: A Deep Dive Into the Struggles and Successes of Reclaiming Sexuality After Sexual Trauma

This study aims to gain insight into the experiences of participants in the “Take Your Sexuality Back” intervention groups, evaluate the intervention’s acceptability, and identify necessary modifications. This study is part of a larger project that seeks to establish a scientific basis for this innovative, group-based treatment to help women who have experienced sexual trauma heal their sexuali…

NCT07214597 — NICU Utilization of Remote Voice Technology to Improve mateRnal Experience (NURTURE)

The study’s objective is to conduct a Phase II randomized controlled trial examining the preliminary efficacy of the VoiceLove app compared to usual care on maternal postpartum depression in mothers with infants admitted to the Neonatal Intensive Care Unit (NICU). Primary aim: Assess the effects of VoiceLove on maternal postpartum depression, measured by the Edinburgh Postnatal Depression Scale…

NCT07249528 — A Study of Voice as a Way to Monitor for Side Effects in People Receiving CAR T-Cell Therapy

The purpose of this study is to collect voice recordings and nervous system (neurologic) assessments from people with non-Hodgkin lymphoma (NHL) or multiple myeloma (MM) who are receiving standard treatment with CAR T-cell therapy. Researchers will study whether these voice recordings and assessments are a practical (feasible) way to monitor for immune effector cell-associated neurotoxicity syn…

NCT07588191 — Effects of Transcutaneous Vagus Nerve Stimulation in Parkinson´s Disease

This study aims to determine whether electrical stimulation of the ear, when combined with physical and speech therapy, can improve symptoms in subjects diagnosed with Parkinson´s disease, by comparing two different application sites.

Each subject will undergo an initial in-person screening and provide consent before participating in the study.

The main questions to answer are:

• Does transc…

NCT07551999 — A Study Of Remote Voice Analysis Tool For Diagnosing And Monitoring ME/CFS

The purpose of this research is to evaluate the use of a voice-based tool in the diagnosis and management of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

NCT07678086 — Effect of Endotracheal Tube Cuff Pressure Management on Postoperative Sore Throat in Pediatric Laparoscopic Appendectomy

Abstract Objective:

The aim of this study is to compare two different ways of adjusting the air-filled cushion (cuff) of the breathing tube used during general anesthesia in children undergoing laparoscopic appendectomy (closed surgery for appendicitis). The goal is to see if maintaining the pressure in this cushion within a safe, specific range (15-18 mmHg) helps prevent or reduce sore throat…

Active, Not Recruiting

NCT04574518 — Teachable Moment to Opt-out of Tobacco: Interactive Voice Response Quit Line for Veteran Active Smokers With Lung Nodules

The purpose of this study is to evaluate the effectiveness of a smoking cessation outreach intervention (TeaM OUT) on increasing use of smoking cessation resources in Veterans. The hypotheses are 1) patients included in the TeaM OUT group will have higher accession of cessation services, such as counseling and medication therapies, compared to patients in enhanced usual care and 2) more patient…

NCT07637591 — Evaluation of a Generative AI-Based Voice Documentation System for Patient-Clinician Communication in the Emergency Department and Its Impact on Clinical Workflow Efficiency and Usability

This research study at Samsung Medical Center evaluates the impact of Ambient AI system, a Generative AI-based communication and documentation system developed by NAVER, on the efficiency and quality of medical record-keeping within the Emergency Department (ED). By converting patient-clinician dialogues into automated medical summaries, the study aims to reduce the administrative burden on hea…

NCT07407413 — Online Socio-emotional Dyad Training for Healthcare Students’ Well-being and Social Skills

In this Edu:Social Health Care project, a randomized controlled trial with a socio-emotional intervention and a waitlist control group will be conducted to evaluate the effects of a partner-based empathy-compassion Dyad mental training (EmCo) intervention on healthcare students with regard to the following primary outcome domains: 1) mental health, 2) resilience, 3) social cohesion and support,…

Not Yet Recruiting

NCT07683767 — Transcranial Magnetic Stimulation in Laryngeal Dystonia

This randomized clinical trial with a crossover design aims to investigate the effects of neuromodulation through repetitive transcranial magnetic stimulation (rTMS) applied to patients diagnosed with laryngeal dystonia. Participants will undergo three experimental conditions: (1) rTMS alone, (2) rTMS combined with speech-language therapy, and (3) sham rTMS combined with speech-language therapy…

NCT07599826 — Active vs. Passive VR During Office-based ENT Procedures

The purpose of this research is to evaluate whether active virtual reality reduces pain and anxiety more effectively than passive virtual reality during office-based ENT procedures. The main procedures include exposure to virtual reality (passive calming scenery or interactive puzzle game) via Paperplane Therapeutics software with VR headset or glasses during common in-office ENT procedures, pa…

NCT07637409 — Online Socio-emotional Dyad Training for School Teachers’ Well-being and Social Skills

The Edu:Social School Study 2 is a randomized controlled trial designed to evaluate the effects of an 8-week socio-emotional, partner-based empathy-compassion Dyad training program (EmCo) compared with a mindfulness-based training (MBT) and a waitlist control group (WLC) in school teachers.

The primary objective is to assess the efficacy of the adapted 8-week online EmCo Dyad training program …

NCT07664748 — Artificial Voice Analysis and Telemonitoring for Heart Failure. A Feasibility Study

Heart failure is a serious condition and a major reason why older adults are admitted to the hospital. Even after going home, many patients struggle to get the follow-up care they need, leading to high rates of return to the hospital.

While remote monitoring technology exists, it is often difficult to use, expensive, or hard for doctors to interpret.

Recent research suggests that changes in a…

NCT07631650 — Bevonescein for Improved Intraoperative Nerve Visualization to Improve Voice Outcomes in Thyroidectomy Patients

Bevonescein (ALM-488) is a novel fluorescein-containing peptide that is intended as a visualization adjunct for the real-time enhanced structural delineation of major nerves during Head and Neck surgery to potentially improve patient outcomes.

NCT07552558 — Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC)

The study is an open-label phase I/II clinical trial. The study will enroll patients to receive neoadjuvant SBRT plus 1 or 2 doses of neoadjuvant pembrolizumab with concurrent ficerafusp alfa (4 doses) prior to definitive surgical resection for high-risk, locoregionally advanced HPV-negative head and neck squamous cell carcinoma (HNSCC). Approximately 6 weeks after end of SBRT, patients will un…

NCT07545148 — Real-world Experiences and Voices Exploring the Actual Lived Burden of OAB: A Mixed-methods Multi-country PROMs Study on OAB Patients’ Quality of Life

The main goal is to understand what it is truly like to live with OAB from the patient’s perspective, including how it affects: daily activities, emotional wellbeing and mental health, social life and relationships, work and overall quality of life.

NCT07333898 — Digital Measurements of Motor and Voice Functions in FTD

The primary objective of this clinical study is to provide the initial validation for monitoring biomarkers of symptoms and functioning for individuals with FTLD syndromes.

Researchers at BioSensics and Johns Hopkins School of Medicine will use wearable sensors, computerized speech, psychomotor, and cognitive assessments to create outcome measures and digital biomarkers for FTLD syndromes. Res…

NCT07637422 — Online Socio-emotional Dyad Training for Healthcare Professionals’ Well-being and Social Skills, Phase II.

Edu:Social Health Care Project Phase II is a non-randomized waitlist-controlled trial with sequential recruitment of the intervention and waitlist control groups (nrWLC), designed to evaluate the effects of a partner-based Dyad-based empathy-compassion mental training (EmCo) intervention on healthcare professionals with regard to following primary outcome domains: 1) mental health, 2) resilienc…

NCT07041203 — Extended-release Sodium Oxybate (Lumryz) in Spasmodic Dysphonia and Voice Tremor

Using a comprehensive approach of clinico-behavioral testing and neuroimaging, the researchers will examine the clinical effects of the extended-release formulation of sodium oxybate on voice symptoms in spasmodic dysphonia in an open-label, proof-of-concept, dose-finding study.

NCT06579989 — Usefulness and Feasibility of Ultrasound in Office Laryngology Procedures

Investigators will assess the usefulness of using ultrasound in office procedures for laryngology interventions. Participants who qualify will be adults who are undergoing superior laryngeal nerve block, injection laryngoplasty, swallowing evaluation, voice evaluation and voice therapy.

NCT07555275 — Testing a Peer-Support Group for Veterans Who Hear Voices

Veterans with schizophrenia spectrum disorders who experience psychosis struggle with social integration- e.g., participation in work, housing, and citizenship-due to symptoms, stigma, and psychosocial functioning deficits. Veteran Voices and Visions (VVV) is a psychosocial, peer-led group intervention for Veterans with psychosis based that reduces distress related to psychosis and fosters a se…

NCT05479643 — A Personalized Voice Restoration Device for Patients With Laryngectomy

The investigators will conduct a pilot experiment for a novel and personalized method for voice restoration using machine learning applied to surface EMG (sEMG) signal from articulatory muscles of the face and the neck allowing recognition of silent speech. The investigators predict that the use novel personalized method for voice restoration will be feasible and successful for patients.

Completed Trials

NCT00449852 — Interactive Voice Response Telephone Technology for the Treatment of Smoking in Patients With Heart Disease

A randomized control trial is planned to evaluate an interactive voice response (IVR) mediated follow-up and triage system, against usual care, to help smokers hospitalized with Coronary Heart Disease (CHD) to quit smoking. The investigators hypothesize that compared to usual care, participants in the IVR group will; a) have a significantly higher 7-day point prevalence abstinence rate at 26 an…

NCT07681557 — Oxidized Regenerated Cellulose and Voice Quality After Total Thyroidectomy

This randomized controlled trial evaluated whether placement of oxidized regenerated cellulose (ORC) over the recurrent laryngeal nerves during total thyroidectomy affects early postoperative voice quality. Patients undergoing bilateral total thyroidectomy for benign or malignant thyroid disease were assigned in a 1:1 ratio to bilateral placement of ORC within the thyroid bed or to conventional…

NCT03027310 — Clinical and Physiological Studies of Tremor Syndromes

Background:

Researchers have some data on how the brain controls movement and why some people have tremor. But the causes of tremor are not fully known. Researchers want to study people with tremor to learn about changes in the brain and possible causes of tremor.

Objective:

To better understand how the brain controls movement, learn more about tremor, and train movement disorder specialists…

NCT05240534 — ElderTree Via a Voice Activated Device for Managing Chronic Health Conditions (NHLBI)

Multiple chronic conditions (MCCs) are costly and pervasive among older adults. MCCs account for 90% of Medicare spending, and 65% of Medicare beneficiaries have 3 or more chronic conditions; 23% have 5 or more. MCCs are often addressed in primary care, where time pressures force a focus on medication and lab results rather than self-management skills. Patients often struggle with treatment adh…

NCT07597954 — Reciprocal Mother-Infant Voice Exposure in the Neonatal Intensive Care Unit

This randomized controlled trial evaluates the effect of reciprocal maternal-infant voice exposure on maternal attachment and breastfeeding outcomes in a neonatal intensive care unit (NICU). Infants in the intervention group are exposed to recordings of their mothers’ voices, while mothers simultaneously listen to recordings of their infants’ sounds between the 6th and 12th postpartum hours. Th…

NCT05158166 — DaxibotulinumtoxinA Injection for Treatment of Adductor Spasmodic Dysphonia

Spasmodic Dysphonia (SD) is a neurologic condition causing inappropriate contraction of the laryngeal musculature, leading to abnormal voicing. The three types (adductor, abductor, and mixed) affect varying muscle groups which produce characteristic voice patterns. The vast majority of patients with SD have adductor type, which impacts the lateral cricoarytenoid and thyroarytenoid muscle comple…

NCT06111027 — Usability of Vibro-tactile Stimulation to Treat Spasmodic Dysphonia

The general aim of the study was to provide evidence for the usability and feasibility of applying vibro-tactile stimulation (VTS) at home as a non-invasive form of neuromodulation to improve speech in people with spasmodic dysphonia (laryngeal dystonia). This work addresses a clinical need to develop alternative or auxiliary treatments for a rare voice disorder with limited treatment options.

NCT06335264 — Screening for Heart Failure Using a Multimodal Wearable Device

The purpose of this study is to find out if there are any patterns in the way people’s bodies react to physical activities and their voices when they have heart failure, a disease where the heart cannot function sufficiently. To do this, the investigators will use a smartwatch that can measure multiple signals like the participant’s heart rate and movement. Investigators will ask participants w…

NCT06345040 — The Dialogue Study: A Virtual-reality Based Treatment for Eating Disorders

The Dialogue Study is a randomized, assessor-blinded parallel-groups superiority clinical trial fulfilling the CONSORT criteria for non-pharmacological treatment. The aim of the trial is to investigate the effect of a new virtual reality based psychotherapy for eating disorders. A total of 96 participants with a diagnosis of anorexia nervosa or bulimia nervosa will be allocated to either Virtua…

NCT05562674 — Impact of VVV Group for Veterans With SMI

Veterans with Serious Mental Illness (SMI) struggle with social integration - participation in work, housing, and citizenship - due to symptoms, stigma, and psychosocial challenges. Despite considerable VA efforts to provide mental health care to Veterans with SMI, programs that promote social integration are lacking. Veterans with SMI are at especially high risk for poor social integration and…

NCT06186570 — Efficacy of an Online-Based Self-Help Intervention for Auditory Hallucinations in Persons With Psychotic Disorders

The proposed clinical trial aims to examine the efficacy of an online-based self-help intervention for auditory hallucinations in persons with psychotic disorders. The intervention is primarily based on Metacognitive Training (MKT) and Mindfulness-Based Group Therapy (MBGT). The investigators will utilize a mixed-method study design within a randomized controlled trial. The intervention group w…

NCT07603778 — Voice Technology to Identify Opioid Use

This study explored whether changes in a person’s voice could help identify opioid use in patients with opioid use disorder (OUD). Current methods for determining whether a patient is intoxicated or in withdrawal often rely on self-reporting and clinical judgment, which can be subjective and inconsistent. Drug tests are logistically challenging to administer and can be costly with repeated use….

NCT07628114 — Logoneurosis. Complete Remission. Clinical Document No. 001. Family System CITADEL 2060: METHODOLOGY “VOICE OF SLEEP MAMABEE 2026-2085”

Training Modules: Three fairy tales Doctrine “Voice of Sleep: MамаBee 2026-2085” Family System: “Citadel 2060”

Systemic work with brain neurons through training modules at the border of sleep in clinical, psychological and strategic logic. Training modules of fairy tale in brain simulation, restoration of the nervous system core in real time. Strategic model of the generational horizon 2026-20…

NCT07008820 — Patient Reported Outcomes and Patient Voice Among Patients Diagnosed With Low Risk Myelodysplastic Syndrome (LR-MDS) or Unexplained Anemia In Japan

This study will examine quality of life, experiences, and unmet needs among individuals diagnosed with Low Risk Myelodysplastic Syndrome who are erythropoietin stimulating agent naïve and non-transfusion dependent and among individuals with suspected myelodysplastic syndromes with unexplained anemia in Japan

NCT07677501 — Combined SOVT and Respiratory Exercises: Effects on MPT and Respiratory Function

This study aims to investigate the effects of combined SOVT and breathing exercises, administered twice weekly for six weeks to conservatory students, through a randomized controlled trial. The study has two hypotheses: H1: Combined SOVT and breathing exercises increase the maximum phonation duration. H2: Combined SOVT and breathing exercises improve spirometric parameters (FEV₁, FVC, FEV₁/FVC,…

NCT07068581 — Effect of Maternal Voice on Physiological Indicators and Feeding Performance

This study aimed to determine the effect of maternal voice on physiological indicators and oral feeding performance in preterm infants.

Hypothesis 1 (H1): Preterm infants who listen to their mother’s voice throughout the full oral feeding process have higher oxygen saturation levels than those who do not.

Hypothesis 2 (H2): Preterm infants who listen to their mother’s voice throughout the ful…

NCT07647159 — Voice Assistant for Outpatient Neurology Visits

Documentation duties account for a substantial portion of an outpatient physician’s working time and reduce time available for direct patient interaction. Voice assistants based on automatic speech recognition and large language models are being developed to automate medical documentation across clinical specialties. However, such ambient AI-based services have not been systematically validated…

Other (Withdrawn)

NCT06129981 — TREATMENT OF POST-TRAUMATIC STRESS DISORDER USING AUGMENTED IMAGINATION EXPOSURE PSYCHOTHERAPY WITH VOCAL FEEDBACK: AN ACCEPTABILITY STUDY

We now have many pharmacological and psychotherapeutic treatments for patients suffering from Post Traumatic Stress Disorder (PTSD), including cognitive and behavioral therapy (CBT) by reactivation of traumatic memories. Despite remarkable initial efficacy, only one-third of patients treated with CBT show lasting clinical improvement. On the other hand, the associated drop-out rates vary from 1…

Other (Suspended)

NCT06985862 — Development of Artificial Intelligence Tools for the Detection of Stress Markers and Consideration of Stress States in the Monitoring of Subjects With Type 1 Diabetes

Stress refers to all the reactions of an organism subjected to exogenous or endogenous stress. In the context of diabetes, stress plays a critical role. There are two forms of stress: acute and chronic, both of which can have a significant impact on patients’ glycaemic control. Acute stress, if repeated, can cause rapid increases in blood glucose levels, while chronic stress can lead to insulin…