Clinical Trials for Premenstrual Syndrome

Source: ClinicalTrials.gov — U.S. National Library of Medicine — A database of privately and publicly funded clinical studies conducted around the world (U.S. National Library of Medicine, public domain).

This page lists clinical trials related to Premenstrual Syndrome from the ClinicalTrials.gov database.

Trial Summary

• Total studies: 50
• Recruiting: 12
• Active, not recruiting: 3
• Completed: 27
• Other: 8

Results are refreshed periodically and may not reflect the most current information available from ClinicalTrials.gov.

Recruiting Trials

NCT07642232 — Effects of Somatic Movement Therapy vs Core Strengthening in Premenstrual Syndrome

Premenstrual Syndrome (PMS) is a multifactorial disorder affecting women of reproductive age, causing physical discomfort, emotional instability, and reduced quality of life. This randomized clinical trial aims to compare the effects of Somatic Movement Therapy (SMT) and Core Strengthening Exercises (CSE) on symptom severity, perceived stress, and quality of life in 34 female participants aged …

NCT06704594 — Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder

Premenstrual dysphoric disorder (PMDD) is a severe affective disorder impacting millions of women worldwide, thought to be due to altered sensitivity to hormone fluctuations across the menstrual cycle. Neuroactive steroid hormones (NAS) and the gamma-aminobutyric acid (GABA)-A receptor (GABAAR) are thought to play a role in PMDD. This research will assess the blood levels of GABAergic NAS, expr…

NCT07084714 — Moderate Aerobic Exercise for Managing Menstrual Cycle Symptoms

The goal of this clinical trial is to evaluate the impact of moderate aerobic exercise on menstrual symptom management in sedentary women both using and not using hormonal contraceptives. The main questions it aims to answer are:

Is there a reduction in physical and/or psychological menstrual cycle related symptom burden with participation in moderate aerobic exercise for sedentary women using…

NCT06496139 — Emotion Regulation-based Internet-delivered Cognitive Behavioural Therapy for Premenstrual Dysphoric Disorder

Premenstrual dysphoric disorder (PMDD) is a debilitating cyclic mental disorder affecting about 2-5% of women of reproductive age. PMDD is characterised by recurring emotional, behavioural, cognitive, and somatic symptoms that arise during the luteal (premenstrual) phase of the menstrual cycle and remit shortly after the onset of menses. Although pharmacological interventions are available, man…

NCT07097558 — Mandala and Music for PMS Relief

Purpose: The aim of this project is to examine the effects of mandala painting and music performance interventions on premenstrual syndrome symptoms and quality of life.

The hypotheses of the study are as follows:

Coloring mandalas has a positive effect on premenstrual syndrome symptoms. Listening to music has a positive effect on premenstrual syndrome symptoms. Listening to music has a posit…

NCT06771583 — Identification and Validation of Epigenetic Biomarkers of PMDD

This research is being done to examine epigenetic markers and mood changes across the menstrual cycle, particularly in premenstrual dysphoric disorder (PMDD). The investigators previously identified epigenetic biomarkers of postpartum depression, another reproductive affective disorder, and in this study aim to determine if these biomarkers also distinguish PMDD cases from healthy controls at d…

NCT07409337 — Self-Acupressure for Primary Dysmenorrhea and Premenstrual Symptoms

This randomized, sham-controlled trial aims to evaluate the effects of self-administered acupressure on menstrual pain severity and premenstrual symptoms in women aged 18-30 years with primary dysmenorrhea. Participants will be randomly assigned to either a self-acupressure intervention group or a sham self-acupressure control group. The intervention will be applied during the premenstrual and …

NCT07686718 — To Establish Whether Individuals With Premenstrual Dysphoric Disorder (PMDD) Demonstrate a Different Luteal-phase Sex Hormone Profile and Ratio Compared With Asymptomatic Controls.

The aim of this project is to compare the ovarian hormone levels 7 days after ovulation and progesterone:oestradiol ratios between PMDD individuals and a control cohort (case control study).

NCT07202650 — THE EFFECT OF GUİDED IMAGERY ON PREMENSTRUAL SYNDROME

EFFECT OF GUIDED IMAGERY ON PREMENSTRUAL SYNDROME IN UNIVERSITY STUDENTS

Premenstrual Syndrome (PMS) is a condition characterized by physical, behavioral, and emotional symptoms that appear at the end of the luteal phase, 7-10 days before menstruation, and resolve with the onset of menstruation. Symptoms include irritability, loss of control, anxiety, depression, sleep disturbances, decreased …

NCT07688720 — Transcutaneous Auricular Neurostimulation (tAN) for Premenstrual Dysphoric Disorder (PMDD) and Perimenopause

Transcutaneous Auricular Neurostimulation (tAN) will be administered to women with premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), and perimenopause. The investigators will examine whether tAN improves symptomology by collecting self-report data before the intervention, during the intervention, and following the intervention.

NCT07679074 — CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life

This study evaluates the feasibility and efficacy of the Samphire Guided Care (SGC) program

• a 12-week structured digital health program combining clinician-led onboarding, at-home neuromodulation using the Lutea tDCS device, neuromodulation coach support, and app-based symptom tracking - on work productivity, employee wellbeing, and quality of life in individuals experiencing mood and cognit…

NCT07684638 — Self-Compassion and Quality of Life in Nursing Students With Premenstrual Syndrome

Premenstrual syndrome (PMS) is one of the most common menstrual disorders among women of reproductive age and is characterized by recurrent physical, emotional, cognitive, and behavioral symptoms during the late luteal phase of the menstrual cycle. These symptoms may adversely affect academic performance, daily functioning, interpersonal relationships, and quality of life. Although previous stu…

Active, Not Recruiting

NCT06462391 — Adapting and Piloting Acceptance and Commitment Therapy (ACT) for Severe Premenstrual Mood Symptoms

In the weeks prior to menstruation, many individuals experience mood and physical symptoms that negatively impact their quality of life and functioning. Approximately 5% of women and menstruating individuals have such severe symptoms that they meet criteria for Premenstrual Dysphoric Disorder (PMDD). Further, of those with underlying mood disorders (i.e., depression, bipolar disorder) about 60%…

NCT07575698 — The Effect of Seed Cycling-Based Nutritional Intervention on Premenstrual Symptoms

This study aims to investigate the effects of the seed-cycling intervention on premenstrual symptoms and nutritional status. At the beginning of the study, written informed consent will be obtained from all individuals who agree to participate.

During the month prior to the intervention, participants’ menstrual cycles will be monitored to determine their menstrual phases. In this period, dieta…

NCT07526623 — Combined Effect of Benson Relaxation Technique and Jacobson Progressive Muscle Relaxation Exercises on Premenstrual Syndrome

Premenstrual syndrome is psycho-physiological stress induced condition including physical, behavioral, and psychological symptoms occur during luteal phase of menstrual cycle (after ovulation) and disappear within a few days after the onset of menstrual cycle .Bloating, breast tenderness, mood swings, food cravings, backache, headache, skin breakouts, depression, lack of energy, irritability, f…

Not Yet Recruiting

NCT07097181 — The Effect of Sensory Awareness Education on Female Students’ Body Awareness and Premenstrual Symptom Levels

This research investigates the effects of web-based sensory awareness training on female students’ body movements.

In order to examine its effect on awareness and premenstrual symptom levels. planned. H0a = Body awareness levels of female students who receive and do not receive sensory awareness training. There is no difference between.

H1a = Body awareness levels of female students who recei…

NCT07171814 — Cohort Study of Honghua Xiaoyao Tablets in the Treatment of Premenstrual Syndrome Based on Target Trial Emulation Framework

To evaluate the efficacy and safety of Honghua Xiaoyao tablets in the treatment of premenstrual syndrome, and the results were further analyzed and evaluated by target trial simulation (TTE) framework.

NCT07189299 — Microdosing LSD in Women With Premenstrual Disorders

The investigators aim to investigate the role of the serotonin 2A receptor in women with premenstrual disorders. This study uses a double-blind, randomized, controlled design with 3 arms: Intervention 1: 10 micg LSD for ~10 days during the late luteal phase (for 3 cycles) Intervention 2: 10 micg LSD every other day for ~10 days during the late luteal phase (for 3 cycles) Control intervention:…

NCT07155720 — Effects of Kinesio Taping on Premenstrual Syndrome

This randomized, single-blind study aimed to evaluate the effects of kinesio taping on PMS symptoms, happiness, and quality of life.

The primary question(s) it aimed to answer were:

Is there a significant difference in premenstrual symptoms, happiness, and quality of life between the kinesio taping intervention group and the sham taping placebo group?

NCT07376759 — Primary Dysmenorrhea and Comfort Theory

Dysmenorrhea is defined as lower abdominal pain experienced during menstruation. It is divided into two types: primary dysmenorrhea and secondary dysmenorrhea. In young women, the majority of dysmenorrhea cases are primary dysmenorrhea. Primary dysmenorrhea has a physical, psychological, and social impact on young women. Pharmacological and non-pharmacological methods are used to treat primary …

NCT07441096 — Efficacy and Safety of Shatavari Root Extract for Premenstrual Syndrome in Women

Premenstrual syndrome (PMS) is a common condition that affects women of reproductive age and is associated with emotional, physical, and behavioral symptoms such as mood swings, irritability, stress, sleep problems, fatigue, and abdominal discomfort. These symptoms typically occur during the days leading up to menstruation and may interfere with daily activities and overall quality of life.

Th…

NCT07684495 — Aerobic Exercises Versus Sub Occipital Myofascial Release on Memory Function in Females With Premenstrual Syndrome.

This study will be conducted to investigate the effect of aerobic exercises versus sub occipital Myofascial release on memory functions in females with premenstrual syndrome.

Enrolling by Invitation

NCT07310485 — Examining the Impact of Phytoestrogens Supplementation on the Gene Expression, and Premenstrual Syndrome in Primenopausal Women

This randomized, double-blind, placebo-controlled clinical trial aims to investigate the effect of flaxseed-derived phytoestrogen supplementation on gene expression of Anti-Müllerian Hormone (AMH) and its receptor (AMHR2), as well as the experience and severity of premenstrual syndrome (PMS), among perimenopausal women aged 40-55 years in Jordan. Participants will receive either flaxseed phytoe…

Completed Trials

NCT00001177 — Study of Premenstrual Syndrome and Premenstrual Dysphoria

The purpose of this study is to identify and describe the symptoms of premenstrual syndrome (PMS).

Women who experience PMS symptoms will complete clinical interviews, self-rating scales, and evaluations of mood and endocrine function. A subgroup of women with severe PMS (Premenstrual Dysphoric Disorder or PMDD) will be offered additional research studies that focus on: 1) identifying the endo…

NCT02777372 — Stress & Premenstrual Symptoms Study

This study that aims to evaluate the psychophysiology of premenstrual mood disorders (PMDs) at baseline and after treatment with sertraline. Participants will include women with PMDs and healthy female controls. Participation involves a baseline visit to determine eligibility and three study visits that include questionnaires and stress reactivity assessment via an acoustic startle paradigm. Fe…

NCT05836454 — The Soft Tissue Mobilization Techniques on PMS

The aim of this study is investigate the effects of progressive relaxation and myofascial release technique on blood flow velocity, pain, premenstrual symptoms and quality of life in premenstrual syndrome patients. There are tree groups in the study. These groups are; progressive muscle relaxation group, myofascial relaxation technique and control group. Evaluations will be made by another phys…

NCT06144073 — The Effect of Mandala Art Therapy in Coping With Premenstrual Syndrome

Mandala practice will be applied to women with premenstrual syndrome. The intervention group (Mandala practice group) and the control group each consisted of 60 women.

NCT07047222 — Improving Menstrual Health Through BCC Among Bangladeshi University Students

This study evaluated the effectiveness of a Behavior Change Communication (BCC) intervention in improving menstrual health among female university students in Bangladesh. The intervention focused on three outcomes: dysmenorrhea, premenstrual syndrome (PMS), and menstrual irregularity (MI), promoting a non-pharmacological, sustainable approach through behavioral and lifestyle changes.

Three str…

NCT07360197 — MBSR for Premenstrual Syndrome and Childbirth Fear

This randomized controlled trial evaluates the effectiveness of a Mindfulness-Based Stress Reduction (MBSR) program on premenstrual symptom severity, fear of childbirth, and psychological well-being in women experiencing Premenstrual Syndrome (PMS). PMS is a prevalent condition characterized by emotional, cognitive, and physical symptoms that significantly impair women’s daily functioning, stre…

NCT06557070 — The Effect of Emotional Freedom Technique on Premenstrual Syndrome

Introduction: Premenstrual Syndrome (PMS) is a condition that occurs in the luteal phase of the menstrual cycle and affects women’s lives physically, psychologically and behaviorally, starting approximately five days before menstruation and decreasing spontaneously a few days later.

Purpose: This research is planned to examine the effect of the Emotional Freedom Technique on the experience of …

NCT07063472 — Kinesio Taping vs Tele-Pilates for PMS

Premenstrual Syndrome (PMS) has a wide variety of signs and symptoms, including physical, psychological, and behavioral symptoms severe enough to disrupt daily activities. Objective: The study aimed to compare the effectiveness of a Tele-Pilates intervention and Kinesio Taping in managing symptoms of premenstrual syndrome (PMS).

NCT07217418 — Music Therapy and Its Effects on Premenstrual Syndrome (PMS)

The purpose of the research is to explore the effects of music therapy on premenstrual syndrome and its symptoms. The goal of this study is to answer the following research questions:

1. Will the passive music listening group and music therapy group (singing and instrumental playing) have a different effect on the physiological responses (EMG, skin conductance, and heart rate) of college stude…

NCT06705660 — Effect of Web-Based Life Style Training and Relaxation Training in Women With Premenstrual Syndrome

The aim of this study is to investigate the effectiveness of web-based lifestyle education and progressive relaxation training provided to women with PMS.

During menstruation, an important indicator of reproductive health, women encounter various problems. One of these problems is premenstrual syndrome (PMS). PMS is characterized by its occurrence in 30-40% of women of reproductive age, beginn…

NCT07078708 — Effectiveness of Non-hormonal Treatment on Moderate to Severe Premenstrual Syndrome

A double-blind, randomised, placebo-controlled, parallel trial was conducted involving 100 females aged 18-40, all of whom presented with premenstrual syndrome at the Department of Gynecology and Obstetrics, Avicenna Medical College Hospital, Lahore, Pakistan. Participants were randomly assigned to two groups of equal size: One group received vitamin D supplementation at a dose of 50,000 IU eve…

NCT07018479 — Effects of a Female Hormone Balance Supplement on Premenstrual Syndrome Symptoms

This virtual single-group study evaluates the effects of the FemmeBalance supplement on symptoms of premenstrual syndrome (PMS) over four menstrual cycles. The study involves daily intake of the supplement, regular questionnaires, and skin photo submissions for dermatological grading.

NCT07461051 — Effects of Foot Bath Therapy on Premenstrual Syndrome Symptoms, Quality of Life, and Pain

The study was conducted as a randomized controlled trial to evaluate the effects of foot bath application on symptom severity, quality of life, and pain levels in women with premenstrual syndrome. The research was carried out with 92 midwifery students. While foot bath therapy was applied to the experimental group, no intervention was performed in the control group. Data were collected through …

NCT06665347 — Effect of Yoga on Psychological Aspect and Quality of Life in Premenstrual Syndrome

This study will be carried out to evaluate the effect of yoga on psychological aspect and quality of life in premenstrual syndrome.

NCT07461766 — Food and Nutrition Education for Adolescent Soccer Players

To identify changes in eating habits and symptoms of premenstrual tension in adolescent athletes before and after a nutritional education program.

NCT07267728 — A Clinical Study to Assess the Effect of a Dietary Supplement on Menstrual Cycle Symptoms

This is a single-group, virtual clinical trial evaluating the effects of a daily dietary supplement (DITTO Cycle Supplement) on menstrual cycle symptoms across three menstrual cycles. The study investigates changes in symptom severity and quality of life through validated questionnaires including the Menstrual Symptoms Questionnaire (MSQ).

NCT06724419 — Efficacy of Nutrition Education in Alleviating Premenstrual Syndrome (PMS) Among Chinese College Students at Hainan University, China

This study aims to evaluate the efficacy of nutrition education-based intervention on PMS severity, perceived stress, and lifestyle-related outcomes among the students at Hainan Vocational University of Science and Technology

NCT07040553 — Effect of Motivational Interviewing and Digital Support on Premenstrual Symptoms and Emotion Regulation

This randomized controlled trial aims to evaluate the effectiveness of an 8-week support program that combines face-to-face motivational interviewing with weekly WhatsApp messages in reducing premenstrual syndrome (PMS) symptoms and improving emotion regulation among university students.

The study was conducted with 70 female students enrolled in the Nursing Department of Erzurum Technical Uni…

NCT06981533 — Auricular Acupressure for Premenstrual Syndrome in Female Students

Premenstrual Syndrome (PMS) is a common gynecological disorder that significantly affects the quality of life for women of reproductive age, with symptoms including emotional, behavioral, and physical disturbances occurring approximately one week before menstruation. PMS is especially prevalent among female undergraduate students, who often experience heightened stress due to academic pressures…

NCT06756477 — The Effect of Mindfulness Training on Premenstrual Syndrome Symptoms and Quality of Life

Premenstrual syndrome (PMS) is an important health problem that negatively affects women’s quality of life by reducing their daily activities, sleep quality, cognitive functioning, interpersonal relationships, academic performance, work and school attendance. Studies show that PMS is associated with unhealthy life behaviors and that PMS can be reduced through the development of healthy life beh…

NCT07118553 — Factors Affecting Premenstrual Syndrome

Premenstrual pain syndrome is a common problem that affects many women of reproductive age. In this study, we aimed to determine whether facial massage would improve the quality of life, mood, pain and stress levels of women with premenstrual syndrome.

NCT07655466 — Effects of Seed Cycling Capsules on Premenstrual Syndrome Symptoms and Menstrual Cycle Length

This virtual, single-arm clinical trial will evaluate the effects of Seed Cycling Capsules on symptoms associated with premenstrual syndrome (PMS) and menstrual cycle characteristics. Forty female participants aged 18 to 45 years will use the study products daily for two menstrual cycles. Participants will complete questionnaires at baseline, at the end of their period during Cycle 1, and at th…

NCT07013539 — Efficacy of a Food Supplement in Relieving Premenstrual Syndrome Symptoms

The aim of this clinical trial, funded by Activ’Inside, is to evaluate the efficacy of a food supplement in relieving Premenstrual Syndrome (PMS) Symptoms. The study will be performed on 110 healthy women who experience mild/moderate Premenstrual Syndrome (PMS) symptoms, under the supervision of a board-certified Gynecologist. Half of the subjects will assume the active product and half of the …

NCT07139223 — The Effect of Laughter Yoga on Premenstrual Syndrome Symptoms and Quality of Life in Young Women

Premenstrual syndrome (PMS) is a common condition among young women, characterized by physical, emotional, and behavioral symptoms that negatively affect quality of life. Laughter yoga, a non-pharmacological mind-body intervention combining breathing techniques, relaxation, and intentional laughter, has been shown to reduce stress, improve mood, and enhance well-being. This randomized controlle…

NCT07646769 — Health Belief Model-Based Podcast Education for Premenstrual Symptoms in University Students

Premenstrual syndrome is a common women’s health condition characterized by physical, psychological, and behavioral symptoms that may negatively affect daily life, academic functioning, and quality of life among young women. This study evaluated the effect of a Health Belief Model-based podcast education program on premenstrual symptom severity and PMS-specific quality of life among young femal…

NCT07074314 — The Effect of Laughter Yoga and Premenstrual Symptoms

Premenstrual Syndrome (PMS) describes somatic, cognitive, emotional, and behavioral symptoms that occur in women during the luteal phase of the menstrual cycle and resolve with the onset of menstruation. These symptoms are common during the reproductive years. The emotional symptoms of PMS include depression, outbursts of anger, irritability, crying spells, anxiety, confusion, social withdrawal…

NCT07599436 — Laughter Yoga and Sleep Hygiene Training for College Students With Premenstrual Syndrome

This study aims to evaluate the effects of laughter yoga and sleep hygiene training on premenstrual syndrome (PMS) symptoms, perceived stress levels, and sleep quality among nursing students.Premenstrual syndrome is a common health issue characterized by physical symptoms as well as emotional fluctuations, anxiety, depressive mood, and behavioral changes, which can negatively impact quality of …