Clinical Trials for Period Pain

Source: ClinicalTrials.gov — U.S. National Library of Medicine — A database of privately and publicly funded clinical studies conducted around the world (U.S. National Library of Medicine, public domain).

This page lists clinical trials related to Period Pain from the ClinicalTrials.gov database.

Trial Summary

• Total studies: 50
• Recruiting: 17
• Active, not recruiting: 5
• Completed: 18
• Other: 10

Results are refreshed periodically and may not reflect the most current information available from ClinicalTrials.gov.

Recruiting Trials

NCT07151274 — Impact of Ehlers-Danlos Syndrome on Gynaecological Health

Dysmenorrhea is a common problem in gynaecology, significantly impacting patients’ quality of life. Ehlers-Danlos syndrome (EDS) is associated with joint hypermobility, tissue fragility and chronic pain. Some studies suggest an increased prevalence of gynaecological disorders, including dysmenorrhea, in patients with EDS. However, data remain limited and few studies have compared the intensity …

NCT07645014 — Comparative Effects of Neurodynamic Stretch and Myofascial Pain Release in Polycystic Ovarian Syndrome.

The study will be a non-blinded randomized controlled trial, consisting of two groups. Non-probability Convenience sampling will be used to recruit participants who will meet the inclusion criteria. Group allocation will be performed using the sealed envelope method to ensure randomization of participants into experimental and control groups. The sample size will be 38 (19 in each group). Group…

NCT07520409 — Effects of Drawing in Maneuver and Resisted Ankle Dorsiflexion in Postpartum Diastasis Recti

The aim of this study is to compare the combine effects of drawing in maneuver and resisted ankle dorsiflexion on pain, inter-recti distance, strength and quality of life in postpartum diastasis recti.

NCT07628452 — Comparative Effects of Aerobic Exercises and Jacobson’s Progressive Relaxation Technique in Primary Dysmenorrhea

The study will focus on the comparative effects of aerobic exercises and Jacobson’s progressive relaxation technique on pain, fatigue and quality of life in primary dysmenorrhea.

This study will be a randomized clinical trial and will be conducted in, Superior college depalpur and Army public schools and college Lahore (APSACS). Non probability convenience sampling will be used to collect the …

NCT07576231 — Effects of Sacral Release Technique and Lumbar Mobilization in Primary Dysmenorrhea.

The aim of this study is to determine the comparative effects of sacral release technique and lumbar mobilization in pain, symptoms severity and quality of life in primary dysmenorrhea.

NCT07260669 — A Phase 2 Trial to Investigate Efficacy and Safety of Vipoglanstat in Women With Endometriosis

The main objective of the trial is to evaluate the efficacy of vipoglanstat on endometriosis-related non-menstrual pelvic pain (NMPP).

NCT07354451 — Pelvic Nerve Mobilization for Primary Dysmenorrhea

Primary dysmenorrhea is a highly prevalent condition among young women and is associated with significant pain, reduced quality of life, and academic absenteeism. Although non-steroidal anti-inflammatory drugs are commonly used, many women seek non-pharmacological alternatives due to limited effectiveness or adverse effects. Emerging evidence suggests that altered pelvic neurodynamics may contr…

NCT07205614 — The Good Pain Consultation in Endometriosis.

This PhD project investigates the effect of “the good pain consultation” and early integration of biopsychosocial pain education with current standard management of endometriosis. Our goal is to facilitate self-management of pain and improve health-related quality of life (HRQOL) using limited resources.

Our research question is: Does a good pain consultation improve pain self-efficacy and HRQ…

NCT06398990 — The Effect of Cognitive Exercise Therapy Approach and Yoga in Adolescents With Dysmenorrhoea

Dysmenorrhoea is a condition that negatively affects the quality of life in women of many age groups. In girls with dysmenorrhoea in adolescence, there is an effect on school performance, self-confidence-depression problems and a decrease in quality of life due to pain. In order to eliminate these negative effects, they should receive a good treatment. Medical treatment usually tries to minimis…

NCT07533669 — Effect of a Preoperative Sensory Modulation Room on Pain, Anxiety, and Sleep in Kidney Transplant Patients

The goal of this prospective study is to evaluate whether preoperative exposure to a sensory modulation room can influence postoperative pain, anxiety, and sleep outcomes in adult living kidney donors and recipients. Organ transplantation involves complex surgical experiences that generate substantial physiological and psychological stress. Increased preoperative anxiety, sleep disturbances, an…

NCT07391930 — High-Intensity Interval Training and Menstrual Health Experience in Primary Dysmenorrhea.

The goal of this study is to evaluate whether a 12-week online supervised high-intensity interval training program can reduce menstrual pain and improve quality of life in women with primary dysmenorrhea. Participants will be divided into two groups: one receiving an educational workshop and the HIIT program, and a control group receiving only the workshop. Additionally, the study seeks to unde…

NCT07302750 — AI-Assisted Relaxation and Breathing Training in Postmenopausal Women

This study aims to evaluate the effectiveness of relaxation and breathing training delivered by a physiotherapist and by an artificial intelligence-assisted system in postmenopausal women with non-specific chronic musculoskeletal pain. Menopause and the postmenopausal period are associated with decreased estrogen levels, structural and functional changes in the musculoskeletal system, increased…

NCT07547618 — Analgesic Consumption in the Early Postoperative Period: A Prospective Observational PACU Study

Postoperative pain remains a significant clinical challenge that directly affects patient recovery, functional outcomes, and overall quality of care. Inadequate pain control in the early postoperative period is associated with delayed mobilization, increased risk of complications, prolonged hospital stay, and the development of chronic pain. The post-anesthesia care unit (PACU) represents a cri…

NCT07618832 — Graded Motor Imagery for Primary Dysmenorrhea

The goal of this clinical trial is to learn if graded motor imagery can reduce pain sensitivity and period pain in women with primary dysmenorrhea (painful periods with no medical cause).

The main questions it aims to answer are:

1. Is there a decrease in pressure pain threshold (increased pain sensitivity) with graded motor imagery?
2. Is the intensity of menstrual pain reduced by graded mot…

NCT07497711 — Virtual Menstrual Pain Approaches in Females

This research study is testing two self-care approaches that may help prevent or reduce period pain in young females with recurrent painful menstrual cramps. Participants will be placed by chance into 1 of 3 groups: auricular acupressure, Baduanjin qigong, or a self-care education comparison group. The auricular acupressure and Baduanjin groups will receive online training and then practice the…

NCT07679074 — CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life

This study evaluates the feasibility and efficacy of the Samphire Guided Care (SGC) program

• a 12-week structured digital health program combining clinician-led onboarding, at-home neuromodulation using the Lutea tDCS device, neuromodulation coach support, and app-based symptom tracking - on work productivity, employee wellbeing, and quality of life in individuals experiencing mood and cognit…

NCT07647276 — Connective Tissue Massage and Music-Based Progressive Muscle Relaxation in Primary Dysmenorrhea

This randomized controlled clinical trial aims to investigate the effects of Connective Tissue Massage (CTM) and music-based Progressive Muscle Relaxation Training (PMRT) on pain intensity, pressure pain threshold, analgesic use, and menstruation-related symptoms in women with primary dysmenorrhea. Participants will be randomly assigned to one of three groups: CTM, music-based PMRT, or control….

Active, Not Recruiting

NCT04333576 — Study Of Oral Elagolix Tablets In Combination With Combined Oral Contraceptive Capsules/Tablets To Assess Dysmenorrhea Response In Adult Female Participants With Endometriosis And Associated Moderate To Severe Pain

Endometriosis is a painful disorder of the uterus affecting 6-10% of women of childbearing age. Endometriosis affects daily activities, social relationships, sexuality and sexual activity, and mental health. This study will evaluate how well elagolix in combination with combined oral contraceptives (COC) works within the body and/or how safe it is compared to placebo (does not contain treatment…

NCT05622708 — A Study of Secukinumab to Evaluate Maintenance of Response in Participants With Non-radiographic Axial Spondyloarthritis Who Achieved Remission

This study will establish whether prolonged chronic dosing with secukinumab is needed in participants with Non-radiographic axial spondyloarthritis, (nr-axSpA) who have achieved remission. Remission is defined as Ankylosing Spondylitis Disease Activity Score - C-reactive protein (ASDAS-CRP) Inactive Disease (ID) response (ASDAS-CRP < 1.3). Maintenance of remission on continued secukinumab trea…

NCT07544511 — Effect of Hand Massage Stimulation on Pain and Menstrual Symptoms in Primary Dysmenorrhea

Purpose of this study: The purpose of this study is to determine the effect of hand massage stimulation techniques on pain, daily menstrual symptoms and nausea and vomiting in primary dysmenorrhea.

H1a: Hand massage stimulation techniques reduce pain in primary dysmenorrhea. H1b: Hand massage stimulation techniques reduce daily menstrual symptoms in primary dysmenorrhea.

The data were collect…

NCT07598929 — AI-Based Education and Menstrual Health Behaviors in Adolescents

This study is designed as a randomized controlled trial aiming to compare the effectiveness of different educational approaches in improving dysmenorrhea self-care and genital hygiene behaviors among adolescent girls. Participants will be allocated into three groups: an artificial intelligence-supported mobile education group, a face-to-face education group, and a brochure-based control group. …

NCT07614607 — Evaluating the Efficacy and Utility of the Automated Pupillometer in Pain Assessment and Opioid Administration Guidance During the Perioperative Period: A Randomized Controlled Trial

Effective intraoperative and postoperative pain management is critical for patient comfort and recovery, yet traditional methods for assessing pain under general anaesthesia are limited by their subjective nature and reliance on vital signs. Automated pupillometry, which gives the parameters of the pupillary light reflex (PLR) components, offers an objective and quantitative approach to evaluat…

Not Yet Recruiting

NCT07612059 — Skin-to-Skin Contact and Lavender Aromatherapy After Elective Cesarean: Effects on Cortisol and Early Breastfeeding

This single-center randomized controlled clinical trial will evaluate the effects of structured early postpartum mother-infant skin-to-skin contact, with or without maternal lavender aromatherapy, after elective cesarean section on maternal stress biomarkers and early breastfeeding outcomes. The study will enroll 150 term pregnant women scheduled for elective cesarean section under spinal anest…

NCT07669883 — Effect of Pilates Exercises Versus Gym Exercises On Primary Dysmenorrhea

This study will be conducted to assess the effect of Pilates Exercises Versus Gym Exercises On Primary Dysmenorrhea.

NCT07658859 — Emotional Freedom Techniques in Nursing Students With Primary Dysmenorrhea

This study will examine whether Emotional Freedom Techniques (EFT) can reduce pain intensity, pain catastrophizing, and functional-emotional impact in nursing students with primary dysmenorrhea. Eligible participants will be randomly assigned to an intervention group or a control group. The intervention group will receive EFT-based support, and the control group will continue their usual coping…

NCT07669285 — Platelet-Rich Plasma Versus Standard Care for Episiotomy Wound Healing in Postpartum Women

This study looks at whether a treatment made from a patient’s own blood, called platelet-rich plasma (PRP), can help heal the cut made during childbirth (episiotomy) better than standard care alone.

PRP is prepared by drawing a small blood sample from the patient and spinning it in a centrifuge to concentrate the platelets, which contain natural healing factors. In this study, women who have a…

NCT07618715 — Pharmacokinetics of Y-4 Tablets With Pregabalin Capsules and Riluzole Tablets in U.S. Healthy Participants

The primary goal of this clinical trial is to compare pharmacokinetic characteristics of Y-4 tablets with pregabalin capsules and riluzole tablets in the US healthy adult participants after single oral administration under fasted condition.

The secondary goal of the trial is to evaluate the safety and tolerability of Y-4 tablets, pregabalin capsules and riluzole tablets in the US healthy adult…

NCT07648342 — Evaluation of Pupillometry as a Predictor of Pain Intensity Upon Withdrawal of Sedation in the Postoperative Period Following Cardiac Surgery: A Prospective Cohort Study

Postoperative pain is a significant issue following surgery, and pain that is either inadequately treated or, conversely, overtreated can increase morbidity. For example, severe chest pain following cardiac or pulmonary surgery impairs the patient’s respiratory rehabilitation, which can lead to fluid retention and, consequently, pneumonia. Conversely, overtreatment through excessive use of opio…

NCT07436507 — Effects of a Combined Home-Based Exercise Program on Menstrual Pain, Dual-Task Gait Performance, and EEG Markers of Cognitive-Motor Control in Females With Primary Dysmenorrhea

What is this study about? Dysmenorrhea, commonly known as painful period, is a common gynecological symptom experienced by several women of reproductive age. This particular type of pain arises during the menstrual cycle, often negatively impacting the quality of life and ability to successfully carry out daily activities and academic or work performance. This is study will involve physiotherap…

NCT07555886 — Intervention in Executive Functions and Emotional Self-Regulation in Adolescents With Primary Dysmenorrhea

Primary dysmenorrhea is one of the most common gynecological conditions during adolescence and is associated not only with recurrent menstrual pain, but also with emotional disturbances and difficulties in behavioral regulation. Various studies have indicated that hot executive functions-linked to emotional processing, decision-making in affective contexts, and impulse control-play a relevant r…

NCT07645196 — Effects of Physiotherapy on Ultrasound and Clinical Parameters in Women With Dysmenorrhea

Dysmenorrhea affects up to 90% of women of reproductive age and represents a significant public health concern. Beyond prostaglandin-mediated uterine contractions, dysmenorrhea involves central sensitization mechanisms and myofascial components, including abdominal trigger points. Despite growing interest in physiotherapy for chronic pelvic pain, objective data on tissue-level changes induced b…

NCT07176780 — Effect of Semiconductor Embedded Wearable Sleeve on Treatment of Primary Dysmenorrhea Symptoms

This study is looking to test a non-compressive semiconductor embedded body sleeve for treatment of primary dysmenorrhea symptoms. Dysmenorrhea is the lower abdominal pain (sometimes referred to as “cramping”) experienced during menstruation (monthly “period”), affecting up to 94% of people aged from 10-20 years old. The semiconductor embedded fabric increases blood circulation through activati…

Completed Trials

NCT03730259 — An Innovative Tailored Intervention for Improving Children’s Postoperative Recovery (WebTIPS)

The goal of this randomized trial is to examine the effectiveness of a tailored Internet-based Preparation Program (WebTIPS) in reducing anxiety and improving the recovery process in children undergoing surgery. Two hospitals and all parent-child dyads will be randomized to either a Web-based Tailored Intervention Preparation for Surgery (WebTIPS) Group or to a Web-based Information (WebINFO) G…

NCT07590232 — Acupuncture for Primary Dysmenorrhea

The main aim is to investigate the effects of acupuncture on pain intensity and health-related quality of life in women with primary dysmenorrhea.

NCT07633990 — The Effect of vırtual realıty on paın and Sleep qualıty ın Women

The aim of this study is to determine whether a video viewed through virtual reality goggles accompanied by music has an effect on pain and sleep quality in women with dysmenorrhea. The main questions it seeks to answer are as follows:

• Does watching a video through virtual reality goggles accompanied by music reduce pain in women with dysmenorrhea?
• Does watching a video through virtual rea…

NCT07677462 — The Relationship Between Ophiocephalus Striatus Extract and Serum TNF-α, IL-6, and CRP Levels in Primary Dysmenorrhea

Primary dysmenorrhea is menstrual pain without any underlying pelvic disease. It affects many adolescent girls and can disrupt daily activities, school attendance, and quality of life. The pain is related to inflammation and the production of substances such as prostaglandins and inflammatory proteins like tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and C-reactive protein (CRP). …

NCT07683637 — Effect of Auricular Vagus Nerve Stimulation on Pain and Symptoms in Primary Dysmenorrhea

This study aims to investigate the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on menstrual pain, pain threshold, depression, anxiety, menstrual symptoms, premenstrual syndrome, and functional and emotional impact of dysmenorrhea in young adult women with primary dysmenorrhea.

NCT07680985 — GyneFix IUD Plus LNG-IUS for Adenomyosis

Adenomyosis is a common gynecological condition that can cause menstrual pain, heavy menstrual bleeding, anemia, and reduced quality of life. The levonorgestrel-releasing intrauterine system is commonly used as a conservative treatment, but displacement or expulsion of the device may occur, especially in patients with an enlarged uterus or a deep uterine cavity.

This study evaluated whether co…

NCT06990815 — Immediate Effects of Kinesio Taping in Primary Dysmenorrhea

Primary dysmenorrhea is characterized by recurrent, cramping lower abdominal pain during menstruation and affects approximately 50% to 90% of women. The etiology of primary dysmenorrhea involves the increased release of prostaglandins and other inflammatory mediators, which cause uterine contractions and reduced blood flow. In addition to pharmacological approaches, non-pharmacological methods …

NCT07563426 — The Effect of Spinal Stabilization Training in Women With Dysmenorrhea

The study, designed as a randomized controlled experimental trial, was conducted at Tonya Vocational School. Institutional approval was obtained to carry out the study at Tonya Vocational School (Appendix-). Participants who met the inclusion and exclusion criteria and voluntarily agreed to participate were required to sign an informed consent form prior to the initiation of the study. Followin…

NCT06673537 — Spinal Manipulation For Menstrual Symptoms and Sleep in Individuals With Primary Dysmenorrhea

The goal of this observational study is to evaluate if spinal manipulation (SM) combined with connective tissue massage (CTM) improves pain, menstrual symptoms, depression levels, and sleep quality in women with primary dysmenorrhea (PD). The main questions it aims to answer are:

Null Hypothesis (H0): SM has no effect on primary dysmenorrhea symptoms, pain severity, depression levels, or sleep…

NCT06705413 — Effect of Lifestyle Modification on Obese Females With Primary Dysmenorrhea

The study will be designed to determine the effect of lifestyle modification on primary dysmenorrhea in obese females.

NCT06674655 — Motor Imagery Plus Therapeutic Exercise in Women With Menstrual Pain

The researchers will conduct a study that combines motor imagery with therapeutic exercise in women experiencing menstrual pain. Previous research suggests that motor imagery, when used alongside physical exercise, may help improve motor control and alleviate pain, potentially enhancing outcomes for individuals dealing with chronic pain conditions. Through this study, the investigators aim to e…

NCT06983600 — The Effect of SuJok Application on Dysmenorrhea and Quality of Life in Young People With Primary Dysmenorrhea:

Menarche, which is one of the most prominent features of maturation in adolescents and the transition from childhood to adulthood, causes many problems. The most prominent of these complaints is dysmenorrhea. Primary dysmenorrhea, the most common form of dysmenorrhea, is a gynecological disorder characterized by pain that starts in the lower abdomen before or during menstruation and radiates to…

NCT06855576 — Bioequivalence Study of Paracetamol With Oral Single Dose Administration in Healthy Adult Subjects Under Fasting Conditions

This study aims to evaluate the bioequivalence of new formulated orodispersible tablet (ODT) containing 500 milligram (mg) paracetamol in comparison to the European marketed Alvedon (paracetamol) 500 mg film-coated tablets and the Australian marketed Panadol (paracetamol) 500 mg film-coated tablets as reference products.

NCT06976151 — Effect of Transcutaneous Electrical Acupoint Stimulation on Dysmenorrhea Among Autoimmune Disease Women

This study will be conducted to investigate transcutaneous electrical acupoint stimulation effect on pain and disease aggravation during menstruation among autoimmune disease women

NCT07237802 — Online Pain Neuroscience Education for Women With Primary Dysmenorrhea

Primary dysmenorrhea is a highly prevalent condition characterized by recurrent menstrual pain in the absence of identifiable pelvic pathology. It affects up to 95% of menstruating women and often interferes with quality of life. Pain neuroscience education (PNE) has shown positive effects in musculoskeletal conditions but has not yet been studied in women with primary dysmenorrhea. This study …

NCT07304583 — The Effect of Playing the Sound of Water and Watching Videos With VR on Urination, Fear, and Pain in Post-Op Children

It was aimed to investigate the effects of watching a video with water sound via virtual reality and listening to the sound of water through headphones on urination, fear and pain in children in the post-operative period.

NCT07052500 — Impact of Seed Cycling on Menstrual Regularity, Dysmenorrhea, and Premenstrual Symptoms

The purpose of this research is to investigate the impact of seed cycling on menstrual regularity, cramps, and pre-menstrual symptoms in women with an irregular menstrual cycle and/or dysmenorrhea. The research seeks to provide evidence-based insights into the potential benefits of seed cycling as a holistic approach to women’s reproductive health.

It is expected that your participation will l…

NCT07314021 — Primary Dysmenorrhea and Mobilization.

72 women diagnosed with primary dysmenorrhea were included in the study and divided into four groups. the first group received treatment with a mobilization approach, the second group received motor imagery-focused exercises and the third group, as a electrotherapy group and fourth received no treatment was applied.