Clinical Trials for Legionnaires' Disease

Source: ClinicalTrials.gov — U.S. National Library of Medicine — A database of privately and publicly funded clinical studies conducted around the world (U.S. National Library of Medicine, public domain).

This page lists clinical trials related to Legionnaires’ Disease from the ClinicalTrials.gov database.

Trial Summary

• Total studies: 9
• Recruiting: 0
• Active, not recruiting: 0
• Completed: 6
• Other: 3

Results are refreshed periodically and may not reflect the most current information available from ClinicalTrials.gov.

Not Yet Recruiting

NCT07352462 — Volatile Organic Compounds Analysis by GC-MS for Diagnostic of Hospitalised Patients With Respiratory Infections Using Exhaled Breath

Emerging respiratory diseases represent a global threat. Viruses such as influenza and coronaviruses have been the main drivers of pandemics over the past century. More broadly, the impact of these respiratory infections is not limited to pandemic risks. Indeed, some of them also trigger seasonal epidemics with a significant medical and economic burden. Consequently, it is essential to strength…

Completed Trials

NCT00467701 — Community Acquired Pneumonia in Telemark and Ostfold

The aim of the study is to investigate the bacterial causes in community acquired pneumonia in adults admitted to hospital in two counties in Norway and to look at possible factors that makes the patients susceptible to pneumonia.

NCT02884700 — Severe Legionellosis Cases Admitted to Grenoble University Hospital, 2006-2011.

The study aimed at further describing the epidemiological, clinical, diagnostic and prognostic features in legionellosis cases admitted to Grenoble University Hospital during the 2006-2011period. The investigators also tested lower respiratory samples collected from these patients during their routine medical care, using a number of molecular tools allowing determination of the involved Legione…

NCT01784770 — Special Investigation Of Azithromycin IV For Legionnaires’ Disease (Regulatory Post Marketing Commitment Plan)

To collect retrospectively the efficacy and safety information of azithromycin IV on patients with Legionnaires’ disease related to their appropriate use in daily practice.

NCT03321786 — Legionnaires’ Effect on Smell

The goal of this study is to determine whether survivors of Legionnaires’ disease suffer smell loss. A quantitative olfactory test will be performed by the participants. Such testing will require approximately 20-30 minutes of the participant’s time. The participants will take the University of Pennsylvania Smell Identification Test (UPSIT), a scratch-and-sniff test to assess their ability to i…

NCT03200275 — Impact of Legionella Urine Antigen Testing (LUAT) on the Local Epidemiology and Diagnosis of Legionella Pneumonia

There has never been a paper published or research done to determine the rate of Legionella species as a cause of community or nosocomial acquired pneumonia requiring hospitalization in Malaysia. Anecdotally, Legionnaires’ disease is thought to be uncommon in Malaysia. This is one of the first prospective hospital-based studies to comprehensively evaluate the epidemiological and demographical f…

NCT04106037 — Nosocomial and Community Acquired Legionella Pneumophila Pneumonia.

Legionnaire’s disease (LD) is a major cause of both community acquired and nosocomial pneumonia, with Legionella pneumophila serogroup A (Lp1) being the most virulent and the greatest cause of disease. Sample culture of low respiratory tract is considered the gold standard in the diagnosis of LD, however its sensitivity seems to be poor and its performance is technically demanding. The introduc…

Other (Terminated)

NCT00452153 — Evaluation of Legionella PCR Techniques for the Routine Diagnosis of Legionellosis

The validity of molecular techniques for the diagnosis of legionellosis is not known. Although PCR can detect Legionella pneumophila (responsible for 80% of legionellosis) and other Legionella species, this test is not recommended in standard guidelines to assess this diagnostic, by contrast to culture of sputum, serology and urine antigen. The aim of this study is to evaluate Legionella PCR te…

Other (Unknown)

NCT03064737 — Bacterial and Human Biomarkers of Prognostic Value for Severe Legionnaire’s Disease

Legionnaires’ disease (LD) is a relatively common pneumonia in France (1200 cases/year), 98% of cases are hospitalized and 40% require intensive care unit (ICU) admission. Risk factors that may predispose to acquisition of LD are well known. Some studies suggest that genetic factor may also enhance susceptibility to LD.

The mortality rate remains high (10% to 33% in ICUs) despite improved diag…