Clinical Trials for Hand Injuries and Disorders

Source: ClinicalTrials.gov — U.S. National Library of Medicine — A database of privately and publicly funded clinical studies conducted around the world (U.S. National Library of Medicine, public domain).

This page lists clinical trials related to Hand Injuries and Disorders from the ClinicalTrials.gov database.

Trial Summary

• Total studies: 50
• Recruiting: 23
• Active, not recruiting: 1
• Completed: 16
• Other: 10

Results are refreshed periodically and may not reflect the most current information available from ClinicalTrials.gov.

Recruiting Trials

NCT03867539 — Exparel and Education to Avoid Opioids After Carpal Tunnel Release

This trial seeks to use the long acting local anesthetic Exparel, in conjunction with opioid education, to attempt to avoid any post-operative opioid use following carpal tunnel surgery. This group will be compared with a “standard” group that receives non-liposomal bupivacaine, opioid education, and opioids.

NCT04057638 — Craniomaxillofacial and Upper Extremity Allotransplantation

The purpose of this study is to evaluate functional and aesthetic outcomes of combined facial and upper extremity composite tissue allografts on patients who have not achieved functional and aesthetic outcomes with conventional reconstructive surgical strategies and prosthetic devices.

NCT03680872 — Restoring Motor and Sensory Hand Function in Tetraplegia Using a Neural Bypass System

This is a single-cohort early feasibility trial to determine whether an investigational device called the Bidirectional Neural Bypass System can lead to the restoration of movement and sensation in the hand and wrist of up to seven individuals with tetraplegia.

NCT05553457 — MyHand-SCI: An Active Hand Orthosis for Spinal Cord Injury

The purpose of this study is to develop and test the hardware and software components of the MyHand-SCI device to assist with hand function for individuals with C6-C7 spinal cord injury.

NCT05588115 — Rapid, Accurate, Cost-effective Assessment of Blood Biomarkers for Diagnosis of Concussion

The goal of this observational study is to test if a biosensor can accurately measure a blood biomarker in adult patients presenting to the emergency department with concussion. The main questions it aims to answer are:

• Does the biosensor measure the blood biomarker of interest with the same accuracy as the current gold-standard assay technique?
• Do relationships exist between blood biomark…

NCT05157282 — Spinal Cord Stimulation for Functional Recovery in Humans With Tetraplegia

In support of the long-term goal of developing new strategies to increase limb function after SCI, the objectives of this proposal are to: 1) Examine the behavioral and physiological effects of TESS on upper-limb muscles after cervical SCI; and 2) Maximize the recovery of reaching and grasping potential by using tailored TESS in a task-specific manner with motor training. Veterans with cervical…

NCT05837286 — Conservative Treatment of Trigger Finger

This study is to analyze the effectiveness of a nighttime extension orthosis after receiving a cortisone injection for the treatment of trigger finger to improve pain and restore functional outcomes. The investigators hypothesize that the extension orthosis will improve pain and functional outcomes compared to those without a digital night extension orthosis in those with trigger finger at 12 w…

NCT05981664 — Level Up! Adaptive Gaming for Children With Upper Limb Differences

The goal of this clinical trial is to test a new one-handed video game controller adapter to determine if it helps improve how video games are played and enjoyed in children with an upper limb difference on one side. The main questions it aims to answer are:

• Is performance improved while playing video games with the adapter?
• Is user satisfaction or enjoyment improved while playing video ga…

NCT05365282 — Association Between Radial Artery Intervention and Development of Neuropathy in the Hand - A Prospective Study

Evaluation of potential nerve damage after radial CAG/PCI.

NCT06838247 — Ultrasonographic Analysis of Post-Traumatic Shoulder Lesions After Hand Trauma

The purpose of the study is to reveal whether there are concurrent shoulder lesions in patients with hand injuries. Its importance is that it will shed light on whether not only the hand but also the shoulder should be included in the treatment program in hand rehabilitation.

NCT06777576 — Self-balancing Personal Exoskeleton for SCI

This study aims to demonstrate the safety and effectiveness of the personal exoskeleton in individuals with spinal cord injury (SCI).

NCT06814015 — Self-balancing Personal Exoskeleton for SCI (Site 2)

This study aims to demonstrate the safety and effectiveness of the personal exoskeleton in individuals with spinal cord injury (SCI).

NCT07222033 — Self-balancing Personal Exoskeleton for SCI (WINY)

This study aims to demonstrate the safety and effectiveness of the personal exoskeleton in individuals with spinal cord injury (SCI).

NCT07410819 — Investigation of the Effectiveness of Cervicothoracic Exercises in Individuals With Carpal Tunnel Syndrome

This randomized, parallel-group controlled clinical trial aims to investigate the effects of adding cervicothoracic exercises to conventional physiotherapy on pain, functional status, grip strength, and range of motion in individuals with carpal tunnel syndrome (CTS). CTS is a common compressive neuropathy of the median nerve, characterized by pain, numbness, tingling, nocturnal symptoms, and r…

NCT07474909 — Perineural vs Intravenous Dexamethasone as an Adjuvant to Brachial Plexus Block in Pediatric Hand Surgery

This clinical trial will evaluate the neurological safety and analgesic effectiveness of dexamethasone administered perineurally or intravenously as an adjuvant to brachial plexus block in children undergoing hand or forearm surgery. Dexamethasone is commonly used to prolong the duration of regional anesthesia, but there is limited evidence on long-term neurological safety, particularly in pedi…

NCT07225582 — Development of Optimal Sensory Feedback Strategies to Maximize Function After Tetraplegia

The goal of this clinical trial is to learn more about how stimulating the nerves involved in sensation (either in the limbs or in the brain) can be used to restore sensation in participants who have a spinal cord injury. Participants in this study will have already been enrolled in the “Reconnecting the Hand and Arm to the Brain (ReHAB)” study, and received small electrodes in a part of the br…

NCT07633769 — Virtual Reality-based Rehabilitation for Traumatic Hand and Wrist Injuries

This randomized controlled trial aims to evaluate the effectiveness of immersive virtual reality (VR)-based Action Observation Therapy (AOT) as an adjunct to conventional rehabilitation in patients with traumatic wrist and hand injuries. Participants will receive standard rehabilitation treatment, and the intervention group will additionally undergo a six-week VR program involving observation a…

NCT07536386 — Self-balancing Personal Exoskeleton for SCI (WIP)

This study aims to demonstrate the safety and effectiveness of the personal exoskeleton in individuals with spinal cord injury (SCI).

NCT07496398 — Median and Ulnar Nerve Function in Tattoo Artists

This case-control study aims to investigate the effects of occupational hand-arm vibration exposure on median and ulnar nerve functions in tattoo artists. Chronic exposure to vibration generated by tattoo machines may lead to neurosensory impairment, reduced tactile sensitivity, and decreased hand strength. Objective assessments including nerve provocation tests, sensory threshold evaluation, t…

NCT07553273 — Vibratory Anesthesia on Pain Following Corticosteroid Injections

This research study aims to evaluate injectional pain at the site of needle insertion for corticosteroid injections (CSI) of the upper extremity depending on different modes of anesthetics. Each individual’s perception of pain upon receiving a CSI with two out of three modes of anesthesia (control/no anesthesia, vibrational anesthesia, vapo-coolant anesthesia) will be utilized to compare these …

NCT07326943 — Minimum Effective Dose of Ropivacaine for Ultrasound-guided Interscalene Block

Inter muscular groove brachial plexus block is a commonly used peripheral nerve block technique in clinical practice, commonly used for anesthesia and analgesia in clavicle, shoulder, and humeral surgeries. The classic ultrasound-guided intermuscular groove block also involves puncturing the needle to the level of the C5/C6 anterior branch for drug injection. After injection, local anesthetics …

NCT07562620 — Video-Based Physiotherapy Education and Social Participation in Adults With Hand Injuries

The goal of this clinical trial is to determine the factors affecting social participation in adult patients with hand injuries and to evaluate the effectiveness of a video-based physiotherapy awareness education in this population.

The main questions it aims to answer are:

Does a short, video-based physiotherapy education increase the knowledge and awareness levels of patients with hand inju…

NCT07539025 — Cervical Spinal Cord Associative Plasticity

Associative plasticity has been used to promote functional recovery from conditions affecting movement. Prior work from the Carmel laboratory has shown that paired associative stimulation protocols timed to converge in the cervical spinal cord induce significantly larger upper limb motor responses than if timed to converge in the motor cortex.

The goal of this prospective experimental study in…

Active, Not Recruiting

NCT07428304 — Cortical Changes After Upper Limb Immobilization Measured by Electroencephalography

This study aims to investigate how temporary immobilization of the upper limb after injury affects brain activity and functional recovery.

Participants with fractures or soft tissue injuries of the upper limb who require immobilization will be evaluated at three time points: at the beginning of immobilization, after removal of the immobilization, and four weeks later.

Brain activity will be m…

Not Yet Recruiting

NCT07423949 — Using Non-invasive Brain and Spinal Cord Stimulation to Improve Arm and Hand Function After Spinal Cord Injury

Cervical spinal cord injury (SCI) disrupts communication between the brain and spinal circuits, affecting voluntary movement control and contributing to arm and hand impairments, the top recovery priority for people with tetraplegia. Although rehabilitation and emerging neuromodulation approaches can support meaningful gains, many individuals experience persistent limitations in reaching and gr…

NCT07535593 — Transcutaneous Electrical Acupoint Stimulation at Jing-Well Points for Disorders of Consciousness

Effective treatment options for disorders of consciousness (DoC) remain limited, and available interventions show heterogeneous efficacy. To date, limited evidences support the use of amantadine and transcranial direct current stimulation in this population.

Bloodletting puncture (BP) at the hand twelve Jing-Well points (HTWPs) has been traditionally used in China as an empirical therapy for D…

NCT07633821 — 3D Hand Orthosis Trial

In people with chronic hand conditions, hand orthoses are frequently prescribed to improve performance in activities of daily living (ADL). Conventional hand orthoses are custom-made on a plaster cast of the hand, a process that is time-consuming and labor-intensive. It has been demonstrated that the production time of manufacturing hand orthoses can be reduced by using 3-dimensional scanning a…

NCT07522060 — Early Functional Response as a Predictor of Clinical Outcomes in Hand Rehabilitation: A Prospective Feasibility Study Using a Digital Monitoring System

This study investigates whether early changes observed during the first weeks of hand and upper extremity rehabilitation can predict patient outcomes months later. In rehabilitation practice, clinicians make numerous decisions each session regarding exercise type, frequency, duration, and treatment approach. Most of these decisions are currently made without systematic longitudinal data. This s…

NCT07660328 — Hand Function Outcome After the Application of Transfer Energy Capacitive and Resistive on Post-burn Patients Presented With Carpal Tunnel Syndrome

Carpal Tunnel Syndrome (CTS) is a common entrapment neuropathy that can develop as a secondary complication following deep burns involving the hand or wrist. Post-burn CTS arises due to factors such as fibrosis, edema, and scar contracture, which may increase pressure on the median nerve within the carpal tunnel, leading to significant pain, sensory disturbances, and impaired hand function Rece…

NCT07668544 — Kinesiophobia and Functional Outcomes in Hand Injuries

Hand and forearm injuries are among the most common traumatic injuries and may result in substantial functional limitations, reduced work capacity, and decreased quality of life. Despite advances in surgical repair techniques, recovery outcomes vary considerably among individuals with similar injury characteristics. Psychological factors, particularly fear of movement or reinjury (kinesiophobia…

NCT07654101 — Isometric Hand-Grip Exercise for Preventing Thrombosis and Occlusion of Midline Venous Catheters: A Randomized Controlled Trial

evaluate whether hand-grip ball exercises reduce thrombosis and occlusions of Midline catheters in hospitalized patients.

NCT07586033 — Prevalence and Functional Impact of Hand and Wrist Symptoms in Ice Hockey Players

Ice hockey places high physical demands on the hands and wrists due to frequent shooting, passing, and physical contact. This study aims to understand how common hand and wrist pain or symptoms are among ice hockey players in Sweden, and how these symptoms affect training, participation, and performance.

Players from different competitive levels (elite, junior, and amateur) and both sexes will…

Enrolling by Invitation

NCT06758193 — Validity and Reliability of the MAP-Hand Scale in Patients With Carpal Tunnel Syndrome

The primary aim of the study was to determine the validity and reliability of the “MAP-Hand (Measure of Activity Performance of the Hand)” scale in patients with carpal tunnel syndrome. The secondary aim of the study was to evaluate the hand activity performance in patients with carpal tunnel syndrome.

Completed Trials

NCT01714349 — Nerve Transfer After Spinal Cord Injuries

Nerve Transfer surgery can provide improved hand function following cervical spinal cord injuries

NCT03482310 — Restoring High Dimensional Hand Function to Persons With Chronic High Tetraplegia

This study is for people who have a paralyzed arm and hand from a spinal cord injury, who have also received a recording electrode array in the brain as part of the BrainGate study. The study will look at the ability of these participants to control different grasping patterns of the hand, both in virtual reality and in his/her actual hand. Movement of the participant’s hand is controlled by a …

NCT05343299 — Postoperative Experience of 2 WALANT-type Modes of Anesthesia Used in Ambulatory Surgery of the Upper Limb.

Distal surgery of the upper limb under local anesthesia using the WALANT technique (Wide Awake Local Anesthesia No Tourniquet) has become the standard care in orthopedic surgery. The principle is that the operator infiltrates the whole surgical area with a 1% lidocaine solution combined with adrenaline (diluted to 1/200,000) so that all distal surgery of the upper limb can be performed without …

NCT05708274 — Pharmacological Agents for Chronic Spinal Cord Injury (SCI)

The purpose of this study is to investigate the short-term effects of 3 approved FDA drugs (cyproheptadine (CPH), carbidopa-levodopa (CD-LD), and atomoxetine (ATX)) on motor responses when delivered in combination with hand training exercises in people with chronic spinal cord injury. The goal is to learn how to better strengthen connections between the brain and spinal cord after spinal cord i…

NCT05887778 — Dexamethasone in Supraclavicular Brachial Plexus Block for Anesthesia After Pediatric Hand/Wrist Surgery

Effect of Systematic Dexamethasone on the Duration of Supraclavicular Brachial Plexus Block for Anesthesia After Pediatric Hand/Wrist Surgery

NCT07370012 — Prism Adaptation Therapy for CRPS Type 1

Complex Regional Pain Syndrome (CRPS) is a clinical condition characterized by pain that arises either without an identifiable triggering factor or with a severity disproportionate to the initiating event. Its progression is typically unpredictable, and most therapeutic interventions yield only partial efficacy. Prism Adaptation Therapy (PAT) is a sensorimotor training method traditionally empl…

NCT07617064 — WALANT Versus Local Anesthesia With Tourniquet for Carpal Tunnel Decompression

This multicenter, randomized, double-blinded controlled trial compared two local anesthetic techniques for open carpal tunnel decompression in adults. The wide-awake local anesthesia no tourniquet (WALANT) technique uses lidocaine with epinephrine and no tourniquet, whereas the conventional technique uses lidocaine only with a pneumatic tourniquet (LA-T). One hundred adults with carpal tunnel s…

NCT07317024 — Additional Effects of Shockwave Therapy Along With Median Nerve Gliding Exercises in Patient With Carpal Tunnel Syndrome.

Carpal Tunnel Syndrome (CTS) is a widespread condition resulting from the compression of the median nerve, causing significant pain, numbness, and weakness in the hand.This study decisively evaluates the impactful effects of integrating shockwave therapy (ESWT) with median nerve gliding exercises.The primary goals are to enhance median nerve function, improve hand performance, and achieve super…

NCT06846788 — Study of Nerve Injuries and Physical Exercise

This study will explore if combining exercise with sensory training can help improve sensory function and reduce pain after an injury to the nerves in the arm and hand. The study will look at how exercise affects the BDNF protein (which helps nerves grow), how it impacts sensation, and how it might help manage pain. Research has shown that exercise is good for brain health, enhancing abilities …

NCT06882707 — The Effectiveness of Neurodynamic Mobilization in Carpal Tunnel Syndrome

This randomized, clinical, single-blinded, controlled study will initially planned to include 86 patients diagnosed with carpal tunnel syndrome who applied to Kütahya Health Sciences University, Evliya Çelebi Training and Research Hospital, Physical Medicine and Rehabilitation outpatient clinic and Kutahya City Hospital.Patients aged 20-55 years who were diagnosed with mild and moderate carpal …

NCT06912217 — Comparison of the Effects of Robotic Rehabilitation, Functional Electrical Stimulation and Occupational Therapy on Upper Extremity and Hand Functions in Tetraplegic Patients With Spinal Cord Injury

2. Purpose and Significance of the Study (Primary and Secondary Objectives, if any) Spinal cord injury (SCI) is a clinical condition characterized by partial or total loss of motor, sensory, and autonomic functions below the level of the lesion, depending on the severity and level of the injury, which may be caused by traumatic or non-traumatic factors.

Globally, the incidence of SCI is estim…

NCT06933511 — Impact of Diabetic Polyneuropathy on Carpal Tunnel Syndrome: Shear Wave Elastography, Ultrasound, and Hand Function

This observational study examines changes in the median nerve in patients diagnosed with diabetic polyneuropathy (DPN) and carpal tunnel syndrome (CTS) using shear wave elastography, microvascular imaging, and cross-sectional area measurements. It also compares the individual and combined effects of type 2 diabetes mellitus, DPN, and CTS on symptoms and hand function.

NCT07417722 — Effects of Peloid Therapy in Patients With Carpal Tunnel Syndrome

Carpal tunnel syndrome is a common condition caused by pressure on a nerve at the wrist. It can lead to pain, numbness, weakness, and difficulty using the hand during daily activities.

In this clinical trial, researchers will study a non-drug treatment approach for people with carpal tunnel syndrome. Participants will be randomly assigned to one of two groups. One group will receive a wrist sp…

NCT07070661 — Radial Pressure Wave Therapy With or Without Parameter Modulation for Carpal Tunnel Syndrome.

This study aims to evaluate the clinical effects of radial pressure wave therapy in patients with a confirmed diagnosis of mild to moderate carpal tunnel syndrome. Participants will be randomly assigned to receive radial pressure wave therapy using either a modulated or a constant parameter dosing protocol. The intervention consists of three weekly sessions, and outcomes will be assessed at bas…

NCT07408596 — “Ultrasound Measures and Clinical Outcomes in Healthy Individuals, Mild and Moderate Carpal Tunnel Syndrome Patients”

“This study aims to investigate ultrasonographic parameters of the median nerve in healthy individuals and patients with mild and moderate carpal tunnel syndrome (CTS).

Specifically, investigator will assess the cross-sectional area (CSA) at the proximal carpal tunnel and the wrist/forearm ratio (WFR), and determine their diagnostic thresholds.

İnvestigators will also evaluate correlations be…

NCT07166029 — Effect of Russian Current on Hand Grip Strength and Functional Outcome After Carpal Tunnel Release

this study will be conducted to investigate the effect of Russian current on hand grip strength and functional outcome after carpal tunnel release

Other (Terminated)

NCT03447509 — Grasping Function After Spinal Cord Injury

The overall goals of this proposal are to examine the contribution of physiological pathways to the control of grasping behaviors after cervical SCI, and to maximize the recovery of grasping by using tailored non-invasive brain stimulation and acoustic startle protocols with motor training. The investigators propose to study two basic grasping behaviors, which are largely used in most daily-lif…