Clinical Trials for Cervical spondylosis

Source: ClinicalTrials.gov — U.S. National Library of Medicine — A database of privately and publicly funded clinical studies conducted around the world (U.S. National Library of Medicine, public domain).

This page lists clinical trials related to Cervical spondylosis from the ClinicalTrials.gov database.

Trial Summary

• Total studies: 50
• Recruiting: 7
• Active, not recruiting: 2
• Completed: 19
• Other: 22

Results are refreshed periodically and may not reflect the most current information available from ClinicalTrials.gov.

Recruiting Trials

NCT05356286 — Recording of Intraoperative Spinal Cord Stimulation and Monitoring

Opioid overdose suppresses brainstem respiratory circuits, causes apnea, and may result in death. Epidural electrical stimulation (EES) at the cervical spinal cord facilitated motor activity in rodents and humans, and we hypothesized that EES of the cervical spinal cord could antagonize opioid-induced respiratory depression in humans. In this study, we will stimulate the spinal cord during surg…

NCT04623593 — Cervical Arthroplasty Cost Effectiveness Study (CACES)

To date, no consensus exists on which anterior surgical technique is more cost-effective to treat cervical degenerative disc disease (CDDD). The most commonly used surgical treatment for patients with single- or multilevel symptomatic CDDD is anterior cervical discectomy with fusion (ACDF). However, new complaints of radiculopathy and/or myelopathy commonly develop at adjacent levels, also know…

NCT04883411 — CEM-Plate and CEM-Cage First-In-Human Use Efficacy Study

The study is a prospective, first-in-human, multi-center, non-randomized, single-arm study to assess the safety and efficacy of the CEM-Cage used with the CEM-Plate in patients who are appropriate candidates for a 2-level anterior cervical discectomy and fusion (ACDF). Fifty patients will be enrolled in the study and, after undergoing a 2-level ACDF, will be evaluated at 4 weeks, 3 months, 6 mo…

NCT05701059 — Comparison of Artificial Disc Implants in Cervical Disc Arthroplasty

This study will comprehensively evaluate the outcomes and endpoints of these two different FDA-approved artificial disc implants used to treat cervical spondylotic myelopathy and/or radiculopathy today: Biomet Zimmer Mobi-C and Nuvasive Simplify. Both implants are structurally different with the Nuvasive Simplify implementing a three-piece design with two endplates and a semi-constrained mobile…

NCT06601634 — Predictors of Axial Pain Improvement After Anterior Cervical Discectomy and Fusion

Neck pain is a common, multifactorial condition. In the case of degenerative cervical spinal disease, it can result from changes in the intervertebral discs, muscles, intervertebral joints, or sagittal imbalance. Anterior cervical discectomy and fusion (ACDF) is a currently widely accepted procedure for treating cervical degenerative spine disease, with a high patient satisfaction rate. In the …

NCT07615491 — PMCF Study on the Effectiveness and Safety of METROSAN Spinal Systems and BONEGRAFT Filling Materials

This is a prospective, multi-center, observational Post-Market Clinical Follow-Up (PMCF) study designed to collect additional safety and clinical performance data on CE-marked Titania® spinal instrumentation and fusion systems, and Bonegraft® bone filling materials (synthetic bone grafts and bone cements). The study aims to evaluate short-term (12-month) safety and effectiveness, identify previ…

NCT07448883 — Validity of the Turkish Translation of the Modified JOA

Degenerative cervical myelopathy (DCM) is the most common cause of non-traumatic spinal cord dysfunction in adults and may lead to progressive motor, sensory, and autonomic impairment. Accurate and standardized assessment of neurological function is essential for clinical decision-making, prognostic evaluation, and comparison of treatment outcomes. The Modified Japanese Orthopaedic Association …

Active, Not Recruiting

NCT02076113 — Cervical Spondylotic Myelopathy Surgical Trial

The purpose of the study is to determine the optimal surgical approach (ventral vs dorsal) for patients with multi-level cervical spondylotic myelopathy (CSM). There are no established guidelines for the management of patients with CSM, which represents the most common cause of spinal cord injury and dysfunction in the US and in the world.

This study aims to test the hypothesis that ventral su…

NCT04968028 — Multi-centre Study to Evaluate ACAF Versus Laminoplasty in Treating Cervical Ossification of the Posterior Longitudinal Ligament

The purpose of this study is to compare the efficacy, safety and imaging outcomes between Anterior Controllable Antedisplacement and Fusion (ACAF) and Laminoplasty in the treatment of severe ossification of cervical posterior longitudinal ligament.

Not Yet Recruiting

NCT06847945 — Observation on the Curative Effect of Acupuncture At Sensitized Points on Gallbladder Meridian in the Treatment of Neck Type Cervical Spondylopathy

To investigate the changes of acupoint sensitization characteristics of patients with Neck Type Cervical Spondylopathy through Gallbladder meridian observe the curative effect of acupuncture intervention and optimize the clinical diagnosis and treatment plan of acupuncture treatment of Neck Type Cervical Spondylopathy

NCT06893185 — Cupping Therapy for Neck Pain in Cervical Spondylosis

Cervical spondylosis is one of the common causes of chronic neck pain. It can significantly affect the quality of life, lead to disabilities, and increase the economic burden on patients. Treatment mainly includes pain relievers, non-steroidal anti-inflammatory drugs (NSAIDs), muscle relaxants or physical therapy. The condition tends to recur frequently; therefore, long-term use of medication c…

NCT07151404 — Efficacy of Acupuncture at Lieque (LU7) for Neck Pain in Cervical Spondylosis

Cervical spondylosis is a common degenerative disorder of the cervical spine that often leads to chronic neck pain, stiffness, and reduced daily functioning. Pain management in these patients remains challenging, and acupuncture is widely used as a non-pharmacological treatment option. However, the additional benefit of stimulating the Lieque (LU7) acupoint, based on the Six Command Points theo…

NCT07230938 — Effects of Neck Proprioception Impairment on Balance in Cervical Spondylosis Patients

This observational cross-sectional study aims to investigate the impact of cervical proprioception deficits on postural stability in patients with cervical spondylosis. Using pedobarographic analysis, the study will assess static balance parameters in affected individuals. The main question it aims to answer is: Does Cervical proprioception deficits affect postural stability in patients with ce…

NCT07309926 — Gait and Paraspinal sEMG in Degenerative Spinal Diseases

This cross-sectional observational study aims to quantitatively compare three-dimensional gait parameters, surface electromyography (EMG) patterns, and radiological parameters among patients with different degenerative spinal conditions-including lumbar disc herniation (LDH), lumbar spinal stenosis (LSS), lumbar sagittal imbalance (LSI), degenerative lumbar scoliosis (DLS), and cervical spondyl…

NCT07502625 — Effect of Vestibular Rehabilitation on Evoked Myogenic Potentials in Patients With Cervical Spondylosis

This study will Investigate the effect of vestibular rehabilitation on:

Primary outcomes: Vestibular evoked myogenic potentials, Balance,and Cervical proprioception.

Secondary outcomes: Functional disability and pain intensity level

NCT07557823 — Transcutaneous Auricular Vagus Nerve Stimulation Combined With Cervical Epidural Injection for Cervical Radiculopathy

This is a prospective, randomized, double-blinded, sham-controlled trial conducted to investigate the efficacy and safety of transcutaneous auricular vagus nerve stimulation (taVNS) combined with cervical epidural injection in the treatment of cervical radiculopathy. A total of 80 subjects will be enrolled and randomly assigned (1:1) to either the experimental group or the control group. The pr…

NCT07559279 — Efficacy Of Jin’s Three-Needle Technique Combined With Electroacupuncture In Cervical Spondylosis With Blood Stasis Syndrome

Neck pain is a highly prevalent condition, affecting 30% to 50% of the population, with cervical spondylosis accounting for up to 80% of these cases. The burden of cervical spondylosis continues to increase, leading to chronic mechanical pain, restricted mobility, and a significant socioeconomic impact. Treatment mainly includes non-steroidal anti-inflammatory drugs (NSAIDs), physical therapy, …

NCT07639060 — Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain

To prospectively describe patient-centered and health utilization outcomes through 12 months after cryoneurolysis performed as routine clinical care for chronic pain at Yale.

NCT07640126 — Efficacy of the “Three-Needle Dazhui” Technique Combined With Electroacupuncture for Cervical Spondylosis With Wind-Cold Syndrome

Cervical spondylosis is a prevalent health issue that significantly impacts quality of life, with Cervical Spondylotic Radiculopathy (CSR) accounting for 60-70% of cases

• While modern medicine offers various treatments, the frequent use of painkillers often leads to undesirable side effects
• In Traditional Chinese Medicine, electroacupuncture is a safe and effective method recognized by the …

NCT07679373 — Effects of Clinical Based Versus Synchronized Telerehabilitation on Pain, Exercise Adherence, and Functional Disability Among Patients With Grade-II Cervical Spondylosis.

This randomized controlled trial aims to compare the effects of clinical-based rehabilitation and synchronized telerehabilitation on pain, exercise adherence, and functional disability in patients with Grade-II cervical spondylosis. A total of 52 participants will be randomly allocated into two parallel groups. Both groups will receive a standardized 6-week rehabilitation program, including cer…

Enrolling by Invitation

NCT04684901 — Effectiveness of AlloWrap® for the Reduction of Inflammation in ACDF Procedures

The primary objective of this study is to obtain evidence of the effectiveness of AlloWrap Amniotic Membrane in the reduction of soft tissue swelling in two-level ACDF procedures.

NCT05066711 — NuVasive® ACP System Study

The primary objective of this study is to evaluate the safety and performance of anterior cervical spine surgery using the NuVasive anterior cervical plate (ACP) System as measured by reported complications, radiographic outcomes, and patient-reported outcomes (PROs).

NCT06591442 — Screening and Prospective Cohort Study of Risk Factors for Enhanced Recovery After Spinal Fusion Surgery in Advanced Age Patient

To determine the high risk factors affecting accelerated recovery after spinal fusion surgery in advanced age patient.

NCT06475365 — Salt Water Gargling on Swallowing Following ACDF

The goal of this randomized control trial is to collect sufficient preliminary data on the efficacy of sodium chloride, hereafter referred to as “saltwater” or “saline” in reducing the difficulty of swallowing following multi-level anterior cervical discectomy and fusion (ACDF) procedures. The study population will consist of generally healthy adults ages 18 - 80. The main question it aims to a…

Completed Trials

NCT01243684 — A Magnetic Resonance Imaging Study of Patients With Cervical Spondylosis

This study aims at evaluating spinal cord structure using diffusion tensor imaging in patients with cervical spondylosis.

NCT02814825 — An ACDF Multi-Center Study Using ViviGen Cellular Bone Matrix

The purpose of this post-market study is to collect data on ViviGen and how its use affects fusion rates in the cervical spine when used as additional grafting material to fill the cervical spacer. The patient population of interest is patients who have already elected to undergo a 2-3 level ACDF surgical procedure using ViviGen, per standard of care.

NCT02931279 — PASS OCT® Post-market Clinical Follow-up

Prospective, multicenter non comparative and observational study (post-market clinical follow-up).

Patients operated with PASS OCT® manufactured by MEDICREA® INTERNATIONAL between July 2016 and July 2017.

The inclusion period will be 12 months and the follow-up 24 months

NCT05006495 — Comparison Between C3-6 Laminoplasty and C3 Laminectomy With Cervical Laminoplasty

Investigators performed a prospective randomized controlled trial for comparing postoperative clinical and radiological outcomes between C3 laminectomy with laminoplasty and C3-6 laminoplasty.

NCT03296592 — Diffusion MRI in Cervical Spondylotic Myelopathy (CSM)

Patients who have been diagnosed with Cervical Spondylotic Myelopathy will be asked to undergo an MRI using diffusion basis spectrum imaging (DBSI) technology. The patients will have this MRI preoperatively and at 24 months postop. The investigators believe that with this imaging, biomarkers will be able to be seen to assist in prediction of long term outcomes in patients with spinal cord compr…

NCT03425682 — ViBone in Cervical and Lumbar Spine Fusion

Assess clinical and radiographic outcomes in patients who undergo 1-3 level anterior cervical discectomy fusion (ACDF) or lumbar interbody fusion (TLIF, PLIF, ALIF, or LLIF) using ViBone.

NCT04544683 — Effectiveness of Cervical Transforaminal Epidural Steroid Injection

Study Purpose:

This study is intended to monitor outcomes for 1 year following cervical TFESI. Based on current clinic volume and enrollment rates into a current study of cervical epidural injections that is nearing completion, we conservatively estimate a study enrollment period of 18 months and a total period of 2.5 years from enrollment to final follow-up data collection. If the study were …

NCT04039581 — KT® in Patients With Cervical Spine Surgery

Aim of the study was to investigate the effect of Kinesio taping application on upper trapezius muscle after cervical spine surgery.

NCT04489394 — Quintex® Follow-up After One Year Minimum

Prospective study, not randomised, non-interventional, monocentric, investigating an intended patient cohort of 60 patients already operated on the cervical spine due to degenerative disc disease of the cervical spine down to the first thoracolumbar VBR (C2-T1), who received a Quintex plate for stabilisation

NCT07069114 — Prognostic Factors for ACDF With BAK/C in Cervical Disc Disease

This retrospective study aimed to identify predictive prognostic factors for treatment outcomes in patients with cervical degenerative disc disease (CDDD). The study analyzed data from 80 patients who underwent anterior cervical discectomy and fusion (ACDF) with the Bagby and Kuslich (BAK/C) technique. Patients were stratified into two groups based on clinical outcomes at a 3-year follow-up, an…

NCT04477447 — PMCF Study on the Safety and Performance of CESPACE 3D

Prospective, pure data collection of all CeSPACE 3D patients in selected centers (not interventional, multicenter)

NCT04852393 — Ultrasound-guided Cervical Medial Branch Blocks

In this study we will prospectively examine the safety and clinical effects of ultrasound-guided cervical medial branch blocks.

NCT06560437 — Effects of the Manual Therapy on Brain Function in Young Chronic Neck Pain Patients

The goal of this clinical trial is to study the central remodeling mechanism of young chronic neck pain patients based on resting-state functional magnetic resonance, and also to study the central analgesic mechanism of Chinese Jingjin Manual Therapy in treating young chronic neck pain patients. The main question it aims to answer are:

Are there specific differences in functional brain activit…

NCT07048288 — Efficacy of Dynamic Exercise and Multi-angle Isometric Exercise in Cervical Spondylosis

Exercises are widely regarded as the primary approach for managing cervical spondylosis. Although several studies have examined the effectiveness of multi-angle isometric exercises and dynamic exercises in patients with cervical spondylosis, their findings have been inconsistent. Further research is warranted to determine whether combining dynamic exercises with Kinesio taping can yield superio…

NCT06351254 — Kinesthetic Exercises and Sine Sound Waves in Cervical Spondylosis

The goal of this Randomized control trial is to determine the Effect of kinesthetic exercises and sound waves on pain, ROM, shoulder alignment and disability in cervical spondylosis. The main question it aims to answer is:

Weather sine sound and kinesthetic exercise are effective in management of pain, rom, alignment, and disability in patients that are suffering from cervical spondylosis

NCT06093997 — Study on the Treatment of C/S of Qi Stagnation and Blood-stasis Type by Moving Cupping With Bloodletting

The goal of this Clinical randomized controlled trial is to evaluate the therapeutic effect of cupping combined with bloodletting in the treatment of cervical spondylosis of qi stagnation and blood stasis type. The main question it aims to answer is: How to remove stasis and prolong the time of promoting blood circulation. Participants will adopt the combination of cupping and bloodletting ther…

NCT07240623 — Comparison of Manual Acupuncture at Distal Acupoints Versus Electroacupuncture at Local Acupoints in Patients With Acute Neck Pain Due to Cervical Spondylosis

This study is a randomized, single-blind, controlled clinical trial involving two groups: manual acupuncture and electroacupuncture, with 62 participants in each group. All participants received treatment once daily for 10 consecutive days, combined with at least 10 minutes of active cervical spine exercises per session.

Participants were allowed to take one 500 mg tablet of paracetamol if the…

NCT06664931 — Muscle Energy Versus Mulligan Techniques in Treating Patients With Cervical Spondylosis

This study will be aimed to answer the following questions:

Which technique, MET or MMT, is more effective in reducing pain, increasing range of motion (ROM), improving proprioception, and enhancing functional ability in individuals with CS?

It will be assumed that:

1. All participants will adhere to study instructions and procedures.
2. All participants will be evaluated under standardized …

NCT06927609 — Kendall Exercises on Posture-Related Cervical Spondylosis

This study evaluates the effectiveness of Kendall exercises in correcting postural deviations, such as forward head posture, associated with cervical spondylosis. By targeting muscle imbalances and improving alignment through stretching and strengthening protocols, the research aims to reduce symptoms, enhance cervical spine function, and promote postural health. Participants will undergo a fou…

Other (Terminated)

NCT02276911 — Safety and Efficacy of Pre-incisional Intravenous Ibuprofen to Reduce Postoperative Pain and Opioid Dependence After Posterior Cervical or Lumbar Instrumented Spine Surgery

A prospective, randomized, placebo controlled, double-blinded study at a single institution.

Other (Unknown)

NCT03320759 — Enhancing Recovery in Non-Traumatic Spinal Cord Injury

The investigators have spent the last decade uncovering unique metabolic and functional abnormalities in the brains of patients with spinal cord compression. Degenerative spinal cord compression represents a unique model of reversible spinal cord injury. In the investigator’s previous work, they have demonstrated that cortical reorganization and recruitment is associated with metabolic changes …

NCT04911257 — Interbody Systems: Post Market Clinical Follow-up Study

This is a prospective, multi-center study of subjects who will undergo spinal fusion surgery utilizing Stryker Interbody Systems that require post market clinical follow up (PMCF).

The primary study hypothesis for each system is that the mean change in NDI (cervical) or ODI (lumbar) from baseline to Month 12 < -10, that is, the mean improvement exceeds 10 points. In supporting analysis, the s…

NCT05910593 — Establishing the Validity and Reliability of a Dexterity Assessment Tool

Every year, thousands of Canadians are diagnosed with degenerative cervical myelopathy (DCM), a form of non-traumatic injury caused by spinal cord compression in the neck. While DCM causes a range of symptoms, one of the most disabling is loss of hand dexterity. Surgical decompression is standard treatment for DCM, but reduced dexterity often remains.

The investigators have developed a portabl…

NCT06130982 — Effects of Different Health Qigong Routines on CS Among Chinese College Students

Health Qigong, originated from Chinese traditional guidance techniques, is known as China’s “six major medical techniques” together with “stone breaking”, “acupuncture and moxibustion”, “massage”, “medicine” and “walking on stilts” of traditional Chinese medicine, and has dual functions of sports and medicine. It mainly takes its own physical activities, breathing, and psychological regulation …

NCT06271525 — Effect of Cupping Therapy on Nitric Oxide Level in Patients With Cervical Spondylosis

this study will be conducted to investigate the effect of cupping therapy on the nitric oxide level in patients with cervical spondylosis

NCT06480175 — Radiofrequency Plus Superficial Cervical Plexus Block in Treatment of Cervical Spondylosis Pain

The goal of this clinical trial is to compare the effectiveness in the pain relief between doing radiofrequency ablation for the medial branch of the cervical facet pain alone vs using it combined with superficial cervical plexus block.in adults patients with cervical spondylosis pain

The main question it aims to answer is:

does adding superficial cervical plexus block to radiofrequency in pa…