Overdose Prevention

Preventing drug overdose and reducing substance use-related harms is a CDC priority.

This content is for informational purposes only. Always consult a healthcare professional.

Source: Centers for Disease Control and Prevention — Content from the Centers for Disease Control and Prevention (public domain).

Patient speaking with their health care provider.

Clinical Drug Test Dashboard

See clinical urine drug test data for adult patients diagnosed with a substance use disorder.

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Apr 16, 2026

Overdose resource exchange provides ready-made tools for action. Find our latest overdose prevention resources today.

ORE Library

Browse our collection of Overdose Resource Exchange materials.

July 29, 2025

Laptop showing data visualization dashboard with bar charts and line graphs

Data Resources

View fatal and nonfatal overdose data dashboards, and pharmacy dispensing rate maps.

May 13, 2026

Free Mind

Drug use and mental health challenges are connected. Discover tools to support teens and parents.

Mar 27, 2026

For Health Care Professionals

Group of clinicians with their arms crossed.

Overdose Prevention for Health Care Providers

Resources for health care providers on pain management, opioids, and opioid use disorder.

May 7, 2024

An upright clipboard presents the 2022 Clinical Practice Guideline as a clinician stands behind it.

Clinical Practice Guideline at a Glance

Overview of the intended use for 2022 Clinical Practice Guideline for prescribing opioids for pain.

May 7, 2024

Clinician holding a pen and using a computer.

Health Care Provider Trainings

Clinician trainings on pain management, opioid use disorder, naloxone, and substance use disorders.

Sept 26, 2025

For Public Health Professionals

Team planning at a conference table

Overdose Data to Action

The hub for CDC’s Overdose Data to Action program, including information and resources.

Mar 19, 2026

high school students standing in a row

Drug-Free Communities (DFC)

Learn about CDC’s Drug-Free Communities Support Program and access related resources.

May 12, 2026

ENGAGE Resource for Action

Use ENGAGE to guide youth substance use prevention efforts in your community.

Xylazine

Xylazine is a non-opioid sedative or tranquilizer. Xylazine is not approved for use in people.

Resources for Public Health Professionals

Find overdose prevention and intervention resources for public health professionals.

Overdose Resource Exchange (ORE)

Overdose Resource Exchange (ORE)

Strategies and Partnerships

Information on overdose prevention strategies and partnerships for healthcare professionals.

⚠ Caution
Medical Disclaimer: This information is for educational purposes only. Always consult a healthcare professional for medical advice.