Sanskrit Verse
यदा तु दूष्यं दोषेभ्यो बलवत्तरं भवति।
— (Sushruta Samhita, Sutrasthana 35/33)
Explanation
This is the crux of pathogenesis (Samprapti). It is the specific, morbid interaction or amalgamation of the aggravated doshas (Dosha) with the susceptible tissues (Dushya) at a site of pre-existing weakness (Kha-Vaigunya). This interaction is the necessary step for the manifestation of a disease’s symptoms.
Clinical Importance
Disease is not just the presence of an aggravated dosha, but its interaction with a body tissue. The entire goal of treatment is to break this interaction (‘Samprapti Vighatana’) by either pacifying the dosha or strengthening the dushya.